Forniceal deep brain stimulation is a promising treatment for several neuropsychiatric disorders as it upregulates synaptic and neurogenesis-associated genes, normalizes genes misregulated in Rett syndrome mice, and regulates genes altered in intellectual disability and major depression.

Simultaneous stimulation and recording in awake-behaving pigeons showed that mid-infrared stimulation, as a promising neuromodulation approach, could facilitate or suppress neuronal firing activity depending on its ongoing sensory responsiveness levels, and cause reversible and gain modulation on sensorimotor behavior.

Integrated imaging analysis of a large multi-center dataset showed that treatment of refractory aggressive behavior with hypothalamic deep brain stimulation is highly effective with specific clinical and neuroimaging features associated with treatment success.

Integrated analysis of transcriptional profiles from mice carrying distinct Mecp2 mutant alleles revealed that MeCP2 regulates Gdf11 expression in the brain, and that Gdf11 is a dosage-sensitive gene whose levels impact neuronal function and animal behavior.

The loss of Mecp2 results in cerebellar dysfunction that contributes to the motor deficits in Rett syndrome.