5,505 results found
    1. Genetics and Genomics
    2. Medicine

    KDM5A mutations identified in autism spectrum disorder using forward genetics

    Lauretta El Hayek et al.
    Successful autism spectrum disorder gene discovery using forward genetics identifies KDM5A, which encodes a histone H3 lysine 4 demethylase, as a disease gene.
    1. Neuroscience

    Nematophagous fungus Arthrobotrys oligospora mimics olfactory cues of sex and food to lure its nematode prey

    Yen-Ping Hsueh et al.
    Genetic and behavior analyses show that Caenorhabditis nematodes are lured to the predator Arthrobotrys oligospora by olfactory mimicry of food and sex cues.
    1. Immunology and Inflammation

    A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells

    Benjamin G Gowen et al.
    Forward genetic screening has provided insight into the molecular mechanisms and stress pathways that promote tumor cell recognition by natural killer cells.
    1. Cell Biology
    2. Neuroscience

    The postsynaptic t-SNARE Syntaxin 4 controls traffic of Neuroligin 1 and Synaptotagmin 4 to regulate retrograde signaling

    Kathryn P Harris et al.
    Syntaxin 4 regulates retrograde signaling in the postsynaptic compartment at Drosophila synapses by controlling trafficking of Neuroligin and Synaptotagmin 4 cargo.
    1. Stem Cells and Regenerative Medicine
    2. Neuroscience

    Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells

    Yaping Sun et al.
    A chemical screen reveals that a compound used to treat a parasitic disease can trigger pluripotent stem cells to become neurons, uncovering a novel mechanism behind neuronal development.
    1. Neuroscience

    Deconstruction of the beaten Path-Sidestep interaction network provides insights into neuromuscular system development

    Hanqing Li et al.
    A network, composed of 22 relatives of the Beaten Path and Sidestep immunoglobulin superfamily cell surface proteins, also includes several neuronal Beaten Path subfamily receptors which interact selectively with Sidestep subfamily proteins expressed on peripheral tissues.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Reduced signal for polygenic adaptation of height in UK Biobank

    Jeremy J Berg et al.
    Many prior signals of polygenic adaptation on human height do not replicate in the UK Biobank.
    1. Cell Biology
    2. Neuroscience

    Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies

    Wei-Hua Lee et al.
    The murine protein TMEM135 is a critical link between aging and age-dependent diseases.
    1. Cell Biology
    2. Neuroscience

    Piezo1 links mechanical forces to red blood cell volume

    Stuart M Cahalan et al.
    In red blood cells, the Piezo1 protein is responsible for sensing mechanical forces and volume regulation.
    1. Genetics and Genomics
    2. Neuroscience

    Usf1, a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice

    Kazuhiro Shimomura et al.
    A gene that codes for a transcription factor that is involved in lipid and carbohydrate metabolism also has a role in the regulation of circadian rhythms.

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