Philip Bejon, Thomas N Williams ... Steffen Borrmann
Malaria 'hotspots' can be identified that range in size from a few homesteads to a village, and it will be necessary to eliminate hotspots at varying scales as we progress towards eliminating malaria.
Ignacio Izeddin, Vincent Récamier ... Xavier Darzacq
While the transcription factor c-Myc explores the space in the nucleus in an unrestricted manner, the elongation factor P-TEFb's sampling of the nucleus is constrained to a complex domain with fractal characteristics.
MotionTracking is freely available software that can generate multi-scale geometrical models of mammalian tissue and perform quantitative analysis of tissue architecture.
Claire M Gillan, Michal Kosinski ... Nathaniel D Daw
A dimensional approach to psychiatry demonstrates the specificity and generalizability of a neurocognitive marker of compulsive behavior and intrusive thought via large-scale online testing.
The spiking activity of the subthalamic nucleus, rather than the activity of striatal projection neurons, orchestrates basal ganglia downstream activity and output commands in health and Parkinson’s disease.
Lieke de Boer, Jan Axelsson ... Marc Guitart-Masip
Attenuated anticipatory activity in ventromedial prefrontal cortex is modulated by dopamine D1 receptor density in nucleus accumbens, and accounts for impaired probabilistic reward learning in older adults.
Ongoing and stimulus-evoked brain activity in cortex are shown in nonhuman primates to follow the organization of neuronal avalanches, a core commonality that might guide optimal information processing in the brain.
The brain has a central cortico-striatal learning circuit that suppresses ongoing pain after injury when actively learning about things that could remove the cause of the pain.
Andrew J Watrous, Jonathan Miller ... Joshua Jacobs
Prospective navigational goals are represented by single neuron firing rates and firing relative to slow oscillatory phase (phase coding) in the human medial temporal lobe.