Functional and mechanistic analyses of cancer cells containing homozygous deletion of TP53 and FXR2 reveal that inhibition of FXR1 blocks cell proliferation in a collateral lethality manner, opening an avenue to develop therapies targeting such cancers.

Drep-2 is the first representative of the evolutionary conserved CIDE-N protein family found at synapses and is required for associative learning by functionally intersecting with metabotropic signaling.

Behavioral and pharmaceutical interventions reverse defects associated with increased cerebellar long-term depression in a mouse model of Fragile X syndrome.

Activity-dependent genetic labeling during behavioral learning shows Fragile-X syndrome model mice exhibit impaired hippocampal engram reactivation, and that enriched environment experience improves fear memory retrieval by enhancing engram reactivation efficacy.

Targeting Abelson kinase can be beneficial for treating disorders characterized by dysregulated Down Syndrome Cell Adhesion Molecule signaling.

Circuit-based intervention corrects irreconcilable excitability defects between dentate granule cells and mossy cells in Fmr1 knockout mice, representing a promising strategy to restore the dentate excitation/inhibition balance and circuit computations.

The capacity for new cerebellum-dependent learning is influenced by the recent history of neural activity in a mouse model of Fragile X syndrome, suggesting a role for metaplasticity.

An ellipse of insignificant analysis is a robust method for ascertaining the strength of even large dichotomous outcome trials in biomedical science, and is a novel means to detect potentially dubious results and research fraud.

Five mouse models of autism show deficits in delay eyeblink conditioning, a form of split-second sensory learning that involves the cerebellum, a frequent site of disruption in autistic brains.

The cryo-EM structural and functional analyses reveals the lactate dehydrogenase/electron-transferring flavoprotein (Ldh-EtfAB) in its enzymatically active form and the geometry of the confurcating flow of two energetically spitted electrons via 2 FAD and 1 [4Fe-4S] cluster to a central FAD.