Damage and repair for both aging mice and humans declined with age, exhibited very long timescales that varied across health attributes, and were differently affected by interventions.

Biological ages have the potential to provide aging-related information beyond chronological age and can be predictive of mortality independently of both chronological age and different types of biological ages.

A comprehensive cross-sectional assessment reveals functional decline in mice consistent with increased energetic cost of physical activity with age through metabolic rewiring in multiple organs.

Late effects of radiation therapy in mice can be prevented by treatment with either senolytics navitoclax or quercetin plus dasatinib or the senostatic metformin.

Long-term increased risks of arrhythmia and heart failure were found in breast cancer patients, while systemic adjuvant therapies including trastuzumab and anthracyclines were associated with the increased risk of heart failure.

A multi-cohort analysis of 2,500 gut microbiomes and five major diseases discovers that disease-microbiome associations display specific age-centric trends, with diseases characterized by age-centric trends of species gain/loss.

Circulating high-molecular-weight (cHMW) adiponectin levels increased with age until centenarians, and the contribution of known major factors associated with cHMW adiponectin levels including BMI varied with age, suggesting that its physiological significance also varies with age in the oldest old.

Prospective, cross-sectional, and intra-twin study designs identify skewed X chromosome inactivation is associated with cardiovascular disease risk and future cancer diagnosis in the TwinsUK population cohort.

A comparison of nine different approaches over a period of 20 years reveals the most promising indicators for biological age.