29 results found
    1. Chromosomes and Gene Expression

    Multi-protein bridging factor 1(Mbf1), Rps3 and Asc1 prevent stalled ribosomes from frameshifting

    Jiyu Wang et al.
    An eukaryotic specific system cooperates with the ribosome quality control pathway to maintain the reading frame during translation of slowly translated sequences.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding

    Chen Bao et al.
    By sterically hindering tRNA binding and inhibiting translation elongation, mRNA stem-loops can modulate gene expression.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Organisms with alternative genetic codes resolve unassigned codons via mistranslation and ribosomal rescue

    Natalie Jing Ma et al.
    Cells resolve unassigned codons with near-cognate suppression, frameshifting, and ribosomal rescue mechanisms, demonstrating that unassigned codons are permissible in both natural and engineered genetic codes as barriers to horizontal gene transfer.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Plasmodium falciparum translational machinery condones polyadenosine repeats

    Slavica Pavlovic Djuranovic et al.
    Adaptations in protein synthesis and mRNA surveillance machinery enabled the malaria-causing parasite P. falciparum to efficiently and accurately translate long polyA nucleotide runs into long poly-lysine peptides.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural insights into mRNA reading frame regulation by tRNA modification and slippery codon–anticodon pairing

    Eric D Hoffer et al.
    Chemical modifications near the tRNA anticodon and specific mRNA–tRNA pairs combine to control the ribosomal three-nucleotide mRNA reading frame, essential for the sequential addition of amino acids into polypeptide chains.
    1. Biochemistry and Chemical Biology

    Genome-wide effects of the antimicrobial peptide apidaecin on translation termination in bacteria

    Kyle Mangano et al.
    Inhibition of bacterial protein synthesis by an antimicrobial peptide apidaecin triggers translation arrest at the stop codons, ribosome queuing and pervasive stop codon readthrough.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    EDF1 coordinates cellular responses to ribosome collisions

    Niladri K Sinha et al.
    Endothelial Differentiation Factor 1 (EDF1) plays a critical role in driving mRNA-specific quality control and global transcriptional responses in response to ribosome collisions.
    1. Cell Biology

    Ribosome collisions trigger cis-acting feedback inhibition of translation initiation

    Szymon Juszkiewicz et al.
    Ribosome collisions along an mRNA are shown to recruit factors that prevent additional ribosomes from initiating translation on that mRNA, thereby providing time to resolve the collision.
    1. Microbiology and Infectious Disease

    Loss of N1-methylation of G37 in tRNA induces ribosome stalling and reprograms gene expression

    Isao Masuda et al.
    Biochemical and genome-wide analysis demonstrates that m1G37 is important for tRNA aminoacylation and for the entire elongation cycle of protein synthesis.
    1. Cell Biology

    Distinct regulatory ribosomal ubiquitylation events are reversible and hierarchically organized

    Danielle M Garshott et al.
    A hierarchical relationship among highly conserved regulatory ribosomal ubiquitylation events and the presence of antagonistic deubiquitylating enzymes suggests a dynamic ubiquitin code impacts ribosome-associated activities.

Refine your results by:

Type
Research categories