4,912 results found
    1. Neuroscience

    Dynamic representation of 3D auditory space in the midbrain of the free-flying echolocating bat

    Ninad B Kothari et al.
    Neurons in the midbrain superior colliculus of free-flying echolocating bats represent 3D sensory space, and the depth tuning of single neurons is modulated by an animal's active sonar inspection of physical objects in its environment.
    1. Structural Biology and Molecular Biophysics

    Large-scale state-dependent membrane remodeling by a transporter protein

    Wenchang Zhou et al.
    The conformational mechanism of a transporter protein is found to have profound and energetically costly effects on the morphology of the surrounding membrane.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Coupled ion binding and structural transitions along the transport cycle of glutamate transporters

    Grégory Verdon et al.
    Crystal structures of an archaeal homologue of mammalian glutamate transporters in apo and ion-only bound outward- and inward-facing states reveal ion-coupled conformational changes supporting mechanisms of coupling, gating, and transport.
    1. Structural Biology and Molecular Biophysics

    Observation of long-range tertiary interactions during ligand binding by the TPP riboswitch aptamer

    Van K Duesterberg et al.
    The combined use of optical trapping and single-molecule FRET permits the study of riboswitch structure formation and conformational dynamics at the same time.
    1. Evolutionary Biology

    Oldest skeleton of a fossil flying squirrel casts new light on the phylogeny of the group

    Isaac Casanovas-Vilar et al.
    Flying squirrels may have originated earlier than previously thought and remained unchanged for almost 12 million years.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The dimerization equilibrium of a ClC Cl/H+ antiporter in lipid bilayers

    Rahul Chadda et al.
    Measuring the equilibrium dimerization of a polytopic membrane protein in lipid bilayers forms the basis of a new system for studying the physical forces that stabilize membrane protein association in membranes.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Recurrent loss of HMGCS2 shows that ketogenesis is not essential for the evolution of large mammalian brains

    David Jebb, Michael Hiller
    The evolutionary loss of the main enzyme required for ketone body biosynthesis suggests that alternative strategies to provide energy for large brains during fasting evolved repeatedly in mammals.
    1. Computational and Systems Biology
    2. Neuroscience

    Prediction of primary somatosensory neuron activity during active tactile exploration

    Dario Campagner et al.
    Primary trigeminal neurons encode rotational forces in awake mice as they explore an object with their whiskers, allowing accurate prediction of spiking during behaviour.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Linking time-series of single-molecule experiments with molecular dynamics simulations by machine learning

    Yasuhiro Matsunaga, Yuji Sugita
    A general machine learning scheme for integrating time-series data from single-molecule experiments and molecular dynamics simulations is proposed and successfully demonstrated for the folding dynamics of the WW domain.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Monitoring site-specific conformational changes in real-time reveals a misfolding mechanism of the prion protein

    Ishita Sengupta, Jayant Udgaonkar
    Multi-site FRET measurements of moPrP oligomerization at low pH indicate that major conformational changes take place as monomers reversibly transform into large oligomers, which subsequently disassemble reversibly into small oligomers.

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