11,146 results found
    1. Cell Biology
    2. Microbiology and Infectious Disease

    General principles for the formation and proliferation of a wall-free (L-form) state in bacteria

    Romain Mercier, Yoshikazu Kawai, Jeff Errington
    A wide range of bacterial species can switch into a cell wall-free state that does not require the FtsZ-based division machinery to proliferate.
    1. Neuroscience

    Neural precursors of decisions that matter—an ERP study of deliberate and arbitrary choice

    Uri Maoz, Gideon Yaffe ... Liad Mudrik
    The readiness potential—a long-established neural precursor of voluntary action claimed to precede the onset of the conscious decision to move—is absent, or at least significantly reduced, for deliberate decisions.
    1. Microbiology and Infectious Disease

    Environmental pH signals the release of monosaccharides from cell wall in coral symbiotic alga

    Yuu Ishii, Hironori Ishii ... Shinichiro Maruyama
    Coral symbiotic alga is capable of degrading the own cell wall components by cellulase-related enzymes and releasing sugars as a simple and autonomous environmental response, even when the host-derived signals are not present.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures of S-OPA1 reveal its interactions with membrane and changes upon nucleotide binding

    Danyang Zhang, Yan Zhang ... Fei Sun
    GTP binding induces rearrangement of S-OPA1 assembly on membrane and thus triggers membrane remodeling with reduced curvature.
    1. Structural Biology and Molecular Biophysics

    The mechanism of mammalian proton-coupled peptide transporters

    Simon M Lichtinger, Joanne L Parker ... Philip C Biggin
    The manner in which protons control the conformational behaviour of mammalian peptide transporters is revealed through state-of-the-art molecular dynamics simulations supported by cell-based assays.
    1. Neuroscience

    Balancing model-based and memory-free action selection under competitive pressure

    Atsushi Kikumoto, Ulrich Mayr
    People compete by trying to outsmart their opponents as long as they win, but show random behavior, and neural signs of suppressing knowledge about opponents’ strategies, when they lose.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Remote immune processes revealed by immune-derived circulating cell-free DNA

    Ilana Fox-Fisher, Sheina Piyanzin ... Yuval Dor
    Cell-free DNA methylation markers allow monitoring of immune and inflammatory cell turnover.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    FLEXIQuant-LF to quantify protein modification extent in label-free proteomics data

    Christoph N Schlaffner, Konstantin Kahnert ... Hanno Steen
    FLEXIQuant-LF provides the framework to enable large-scale identification of differentially modified peptides and quantification of their modification extent in label-free mass spectrometry data without prior knowledge of the modification type.
    1. Neuroscience

    Control of entropy in neural models of environmental state

    Timothy H Muller, Rogier B Mars ... Jill X O'Reilly
    Evidence for neuromodulatory control of flexibility in human neural models.
    1. Cancer Biology
    2. Genetics and Genomics

    Unsupervised detection of fragment length signatures of circulating tumor DNA using non-negative matrix factorization

    Gabriel Renaud, Maibritt Nørgaard ... Søren Besenbacher
    Non-negative Matrix Factorization is a powerful strategy for unsupervised analysis of cell-free DNA that enables simultaneous estimation of the blood tumor fraction and the fragment length distribution of circulating tumor DNA.

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