In vivo inhibition of SUMO activating E1-enzymes by pyrophosphate reveals a mode of integrating metabolism and stress tolerance that is conserved across kingdoms.
Roundworms and yeast can survive extreme desiccation only by switching their metabolism into a gluconeogenic mode and producing very high amounts of trehalose via the glyoxylate shunt.
Cytokinin-dependent manipulation of plant metabolism is a strategy employed not only by gallers and leaf-miners but also by a free-living insect, Tupiocoris notatus, which directly transfers cytokinins at feeding sites to manipulate its host plant.
The insect dopaminergic system serves an important function in the regulation of ontogenesis and early development, contributing to the evolutionary processes that limit the ecological niche of Drosophila sechellia.
The major protein disulfide isomerase family member, PDIA1, is essential in beta cells of mice fed a high-fat diet to maintain glucose homeostasis, proinsulin maturation and organelle integrity.
Genetic inactivation of the transcription factor, Zfp423, in visceral white adipocyte precursors leads to the formation of thermogenic adipocytes in visceral fat depots and improves insulin sensitivity in obese mice.
Exposure to Bacillus thuringiensis (Bt) selects for beneficial interactions between the target insect pest (Helicoverpa armigera) and its symbiotic densovirus that enhances its performance on Bt-crops under field conditions.
Class 1 histone deacetylase (HDAC) inhibitor MS-275 enhances the efficacy of glucagon-like peptide 1 receptor (GLP-1R) therapy for glycemic control and reduction of obesity.
