108 results found
    1. Developmental Biology

    The Glide/Gcm fate determinant controls initiation of collective cell migration by regulating Frazzled

    Tripti Gupta et al.
    The role of the Frazzled chemoattractant receptor is to triggers migration initiation as part of the glial developmental program induced by the Glide/Gcm transcription factor.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice

    Yuyong Tao et al.
    Modular tetravalent antibodies can be engineered to stimulate signaling through any combination of Frizzled and LRP receptors to drive organoid growth and mobilize endogenous stem cells in vivo.
    1. Cancer Biology
    2. Developmental Biology

    Norrin/Frizzled4 signalling in the preneoplastic niche blocks medulloblastoma initiation

    Erin A Bassett et al.
    The earliest steps of tumor initiation in the cerebellum are regulated by critical interactions between pre-tumor cells and stromal cells, which can be manipulated by targeting the Norrin/Frizzled4 signaling axis.
    1. Neuroscience

    Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons

    Zhong L Hua et al.
    The signaling molecule Frizzled3 plays a part in the development of the nervous system by controlling the ability of motor neurons to form connections with distant target muscles.
    1. Cell Biology
    2. Developmental Biology

    Light-activated Frizzled7 reveals a permissive role of non-canonical wnt signaling in mesendoderm cell migration

    Daniel Čapek et al.
    Uniform activation of Frizzled7 signaling is required and sufficient for directional mesendoderm cell migration during zebrafish gastrulation.
    1. Developmental Biology
    2. Neuroscience

    Molecular determinants in Frizzled, Reck, and Wnt7a for ligand-specific signaling in neurovascular development

    Chris Cho et al.
    Molecular dissection of Frizzled, Reck, and Wnt7a provides critical insight into the long-standing question of ligand-receptor specificity in the field of Wnt signaling.
    1. Structural Biology and Molecular Biophysics
    2. Developmental Biology

    Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan

    Tao-Hsin Chang et al.
    The crystal structure of Norrie Disease Protein in complex with the extracellular cysteine-rich domain of Frizzled4 receptor and sucrose octasulfate reveals binding sites for Frizzled4, low density lipoprotein receptor related protein 5/6, and proteoglycan.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Elastic instability during branchial ectoderm development causes folding of the Chlamydosaurus erectile frill

    Sophie A Montandon et al.
    Robust wrinkling pattern of the frilled dragon’s spectacular erectile ruff emerges from an elastic instability during homogeneous growth of the embryonic neck fold frustrated by its attachment to adjacent tissues.
    1. Developmental Biology
    2. Neuroscience

    Frazzled promotes growth cone attachment at the source of a Netrin gradient in the Drosophila visual system

    Orkun Akin, S Lawrence Zipursky
    Direct observation in the developing fly brain indicates that the response of a growth cone in a gradient of a guidance cue is adhesion to the source of the cue rather than attraction by the gradient.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Morphogenesis: Mathematical models with frills

    Pierre A Haas
    The spectacular frill around the neck of the lizard Chlamydosaurus has its origins in a mechanical instability that arises during development.
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