1,393 results found
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Development of equation of motion deciphering locomotion including omega turns of Caenorhabditis elegans

    Taegon Chung, Iksoo Chang, Sangyeol Kim
    ElegansBot, a two-dimensional rigid body chain model, simulates various locomotion of C. elegans, including omega and delta turns, using Newtonian equations of motion.
    1. Neuroscience

    Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors

    Austin R Graves, Richard H Roth ... Richard L Huganir
    A knockin mouse line was made to label endogenous AMPA receptors, enabling direct observation of synaptic plasticity in behaving animals with single-synapse resolution across the entire brain.
    1. Cell Biology
    2. Neuroscience

    Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of huntingtin

    Julie Bruyère, Yah-Se Abada ... Frédéric Saudou
    Reducing Akt-mediated huntingtin phosphorylation decreases APP accumulation at the synapse by reducing its anterograde axonal transport and ameliorates learning and memory in a mouse model of familial Alzheimer disease.
    1. Neuroscience

    Synaptic plasticity and cognitive function are disrupted in the absence of Lrp4

    Andrea M Gomez, Robert C Froemke, Steven J Burden
    Lrp4 mutant mice display profound deficits in cognitive tasks that assess learning and memory with disruptions in the subcellular organization of synaptic inputs and synaptic plasticity in the hippocampus.
    1. Cell Biology

    Differential axonal trafficking of Neuropeptide Y-, LAMP1-, and RAB7-tagged organelles in vivo

    Joris P Nassal, Fiona H Murphy ... Matthijs Verhage
    In vivo live imaging reveals the trafficking dynamics of three cellular organelles in neocortical axons with single vesicle resolution and demonstrates activity-dependent changes.
    1. Neuroscience

    NPAS4 in the medial prefrontal cortex mediates chronic social defeat stress-induced anhedonia-like behavior and reductions in excitatory synapses

    Brandon W Hughes, Benjamin M Siemsen ... Makoto Taniguchi
    Social defeat stress induces transcription factor Npas4 expression in the medial prefrontal cortex and its chronic stress-induced changes in excitatory synaptic transmission, reduction of dendritic spine density, and anhedonia-like behaviors.
    1. Neuroscience

    Distinct synaptic transfer functions in same-type photoreceptors

    Cornelius Schröder, Jonathan Oesterle ... Tom Baden
    The ribbon synapses of zebrafish UV-cone photoreceptors preferentially transmit transient or sustained components in light-stimuli depending on their location in the eye.
    1. Cell Biology
    2. Neuroscience

    EFHC1, implicated in juvenile myoclonic epilepsy, functions at the cilium and synapse to modulate dopamine signaling

    Catrina M Loucks, Kwangjin Park ... Michel R Leroux
    C. elegans EFHC1 influences neuronal transmission through the cilium and the synapse.
    1. Neuroscience

    Hidden synaptic differences in a neural circuit underlie differential behavioral susceptibility to a neural injury

    Akira Sakurai, Arianna N Tamvacakis, Paul S Katz
    Animal-to-animal variability in neural circuit elements is often hidden under normal conditions, but becomes functionally relevant when the system is challenged by injury.
    1. Neuroscience

    The wiring diagram of a glomerular olfactory system

    Matthew E Berck, Avinash Khandelwal ... Albert Cardona
    The complete neural circuit map of a tractable olfactory system will support studies towards bridging the gap between circuits and behavior.

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