Allostery in an intrinsically disordered domain of glucocorticoid receptor is mediated by opposing thermodynamic signals that are directed through the production of different isoforms.

A disordered region at the N-terminus of the glucocorticoid receptor can fine tune how cells respond to a hormone via an allosteric mechanism.

Recruiting PhD students can be a frustrating process, but Eve Marder looks forward to welcoming the latest crop in the autumn.

An over-emphasis on novelty is having detrimental effects on science.

A university genomics class provides detailed examples of how to design and execute Oxford Nanopore MinION hackathons as part of an academic curriculum.

Eve Marder believes that many of the most important events in our lives, both personal and professional, depend to some degree on luck or chance.

Proposals to reduce the number of students who do PhDs are misguided because they would exclude young scientists with qualities that do not show up in exam results and interviews.

Editors, reviewers and authors share their experiences of consultative peer review at eLife.

Individual scientists, scientific communities and scientific journals can do more to assess the publication of irreproducible results, to promote good science, and to increase the efficiency with which the scientific community self-corrects.