63 results found
    1. Structural Biology and Molecular Biophysics

    Genetically tunable frustration controls allostery in an intrinsically disordered transcription factor

    Jing Li et al.
    Allostery in an intrinsically disordered domain of glucocorticoid receptor is mediated by opposing thermodynamic signals that are directed through the production of different isoforms.
    1. Structural Biology and Molecular Biophysics

    Protein Dynamics: Proteins acting out of (dis)order

    David Eliezer
    A disordered region at the N-terminus of the glucocorticoid receptor can fine tune how cells respond to a hormone via an allosteric mechanism.
    Insight
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  1. Living Science: The rites of spring, Take 2

    Eve Marder
    Recruiting PhD students can be a frustrating process, but Eve Marder looks forward to welcoming the latest crop in the autumn.
  2. Point of View: How should novelty be valued in science?

    Barak A Cohen
    An over-emphasis on novelty is having detrimental effects on science.
  3. Cutting Edge: Using mobile sequencers in an academic classroom

    Sophie Zaaijer et al.
    A university genomics class provides detailed examples of how to design and execute Oxford Nanopore MinION hackathons as part of an academic curriculum.
  4. Living Science: Looking out for future scientists

    Eve Marder
    Proposals to reduce the number of students who do PhDs are misguided because they would exclude young scientists with qualities that do not show up in exam results and interviews.
  5. Living Science: Luck, jobs and learning

    Eve Marder
    Eve Marder believes that many of the most important events in our lives, both personal and professional, depend to some degree on luck or chance.
  6. Peer Review: Consultative review is worth the wait

    Stuart RF King
    Editors, reviewers and authors share their experiences of consultative peer review at eLife.
    1. Cancer Biology

    Reproducibility Project: Cancer Biology: Time to do something about reproducibility

    Sean J Morrison
    Individual scientists, scientific communities and scientific journals can do more to assess the publication of irreproducible results, to promote good science, and to increase the efficiency with which the scientific community self-corrects.
    Editorial
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