119 results found
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Local frustration determines loop opening during the catalytic cycle of an oxidoreductase

    Lukas S Stelzl et al.
    The cysteine pair oxidation state in nDsbD acts as a ‘switch’ controlling the presence or absence of frustration in the active-site and determining the dynamic behavior of the cap loop.
    1. Structural Biology and Molecular Biophysics

    Genetically tunable frustration controls allostery in an intrinsically disordered transcription factor

    Jing Li et al.
    Allostery in an intrinsically disordered domain of glucocorticoid receptor is mediated by opposing thermodynamic signals that are directed through the production of different isoforms.
    1. Physics of Living Systems

    Shape selection and mis-assembly in viral capsid formation by elastic frustration

    Carlos I Mendoza, David Reguera
    Nucleation, elasticity theory, and simulations were combined to construct a general phase diagram that elucidates the conditions for successful viral assembly and the key factors to prevent it.
    1. Structural Biology and Molecular Biophysics

    Protein Dynamics: Proteins acting out of (dis)order

    David Eliezer
    A disordered region at the N-terminus of the glucocorticoid receptor can fine tune how cells respond to a hormone via an allosteric mechanism.
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  1. Living Science: The rites of spring, Take 2

    Eve Marder
    Recruiting PhD students can be a frustrating process, but Eve Marder looks forward to welcoming the latest crop in the autumn.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Morphogenesis: Mathematical models with frills

    Pierre A Haas
    The spectacular frill around the neck of the lizard Chlamydosaurus has its origins in a mechanical instability that arises during development.
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  2. Point of View: How should novelty be valued in science?

    Barak A Cohen
    An over-emphasis on novelty is having detrimental effects on science.
  3. Cutting Edge: Using mobile sequencers in an academic classroom

    Sophie Zaaijer et al.
    A university genomics class provides detailed examples of how to design and execute Oxford Nanopore MinION hackathons as part of an academic curriculum.
  4. Living Science: Looking out for future scientists

    Eve Marder
    Proposals to reduce the number of students who do PhDs are misguided because they would exclude young scientists with qualities that do not show up in exam results and interviews.

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