9 results found
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    An essential, kinetoplastid-specific GDP-Fuc: β-D-Gal α-1,2-fucosyltransferase is located in the mitochondrion of Trypanosoma brucei

    Giulia Bandini et al.
    The activity, localization, and essentiality of TbFUT1, together with its ability to complement Leishmania parasites lacking the homologous gene, suggest the presence of an uncommon and conserved mitochondrial fucosylation pathway required for kinetoplastid parasites viability.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Fucosylation and protein glycosylation create functional receptors for cholera toxin

    Amberlyn M Wands et al.
    Cholera intoxication of human colonic epithelial cells is dependent on recognition of protein glycosylation and fucosylation, not exclusively on ganglioside recognition as proposed previously.
    1. Immunology and Inflammation

    Epigenetic modification of the PD-1 (Pdcd1) promoter in effector CD4+ T cells tolerized by peptide immunotherapy

    Rhoanne C McPherson et al.
    Peptide immunotherapy in mice depends upon sustained expression of co-inhibitory protein PD-1 in T cells.
    1. Immunology and Inflammation

    High-endothelial cell-derived S1P regulates dendritic cell localization and vascular integrity in the lymph node

    Szandor Simmons et al.
    Impairment of the autocrine S1PR1-Gi signaling on HEVs results in high-endothelial cell apoptosis, reduced CCL21-secretion from HEVs, and cessation of HEV-DC interactions and lymphocyte immigration across the high-endothelial barrier.
    1. Developmental Biology

    The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro

    Lena Tveriakhina et al.
    Regions outside the major receptor binding interface of DLL1 and DLL4 contribute to context-dependent divergence of ligand function in vivo and differential Notch1 and Notch2 activation in vitro.
    1. Cell Biology
    2. Developmental Biology

    Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates

    Martin L Basch et al.
    The cochlea deploys two Fringe proteins at exactly the same time and position to regulate a novel mode of Notch signaling that sets the boundary of the organ of Corti, the ear's hearing organ.
    1. Immunology and Inflammation

    C/EBPδ drives interactions between human MAIT cells and endothelial cells that are important for extravasation

    Chang Hoon Lee et al.
    The bZIP transcription factor C/EBPδ enhances expression both of selectin ligands and the chemokine receptor CCR6 on human mucosal-associated invariant T cells, supporting their efficient extravasation into inflamed tissue.
    1. Developmental Biology

    Co-expression of Foxa.a, Foxd and Fgf9/16/20 defines a transient mesendoderm regulatory state in ascidian embryos

    Clare Hudson et al.
    Ascidian mesendoderm is a transient regulatory state upstream of mesoderm and endoderm gene regulatory networks and required for the initiation of both.
    1. Epidemiology and Global Health
    2. Medicine

    An agnostic study of associations between ABO and RhD blood group and phenome-wide disease risk

    Torsten Dahlén et al.
    The relationship between blood groups and disease is detangled, without preconceived ideas, using population-wide data, with millions of participants and lifetime follow-up, identifying not only previously known relationships but also new insights.

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