4,827 results found
    1. Computational and Systems Biology
    2. Neuroscience

    On the objectivity, reliability, and validity of deep learning enabled bioimage analyses

    Dennis Segebarth, Matthias Griebel ... Robert Blum
    A comparison of different bioimage analysis pipelines reveals how deep learning can be used for automatized and reliable analysis of fluorescent features in biological datasets.
    1. Computational and Systems Biology

    A computational interactome and functional annotation for the human proteome

    José Ignacio Garzón, Lei Deng ... Barry Honig
    A machine-learning approach is used to predict 1.35 million interactions for 85% of the human proteome.
    1. Neuroscience

    The Mouse Action Recognition System (MARS) software pipeline for automated analysis of social behaviors in mice

    Cristina Segalin, Jalani Williams ... Ann Kennedy
    The Mouse Action Recognition System is a computational pipeline for automated classification of social behaviors in freely interacting mice, accompanied by a graphical interface for analysis of multimodal neuroscience datasets.
    1. Genetics and Genomics
    2. Structural Biology and Molecular Biophysics

    Structure-guided isoform identification for the human transcriptome

    Markus J Sommer, Sooyoung Cha ... Steven L Salzberg
    The ability to accurately predict a protein's structure gives us an entirely new way to annotate the human genome.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Prediction of enzymatic pathways by integrative pathway mapping

    Sara Calhoun, Magdalena Korczynska ... Andrej Sali
    A computational method identifies the functions of orphan enzymes by organizing them into metabolic pathways; the prediction of a new l-gulonate catabolic pathway is experimentally tested and confirmed.
    1. Microbiology and Infectious Disease

    A framework for community curation of interspecies interactions literature

    Alayne Cuzick, James Seager ... Kim E Hammond-Kosack
    A framework has been devised that enables global participation in the curation of publications on any topic involving two or more living organisms, ranging from microscopic to larger sizes, in their natural or artificial environments or ecosystems.
    1. Neuroscience

    Fast and accurate annotation of acoustic signals with deep neural networks

    Elsa Steinfath, Adrian Palacios-Muñoz ... Jan Clemens
    DAS is a universal tool for segmenting and identifying acoustic signals in single and multi channel recordings robustly, reliably, and at low latency.
    1. Cell Biology
    2. Computational and Systems Biology

    Identifying molecular features that are associated with biological function of intrinsically disordered protein regions

    Taraneh Zarin, Bob Strome ... Alan M Moses
    A statistical model systematically associates functions of intrinsically disordered regions with sequence-distributed molecular features such as charge, residue composition, or repeat content.
    1. Computational and Systems Biology

    ProteInfer, deep neural networks for protein functional inference

    Theo Sanderson, Maxwell L Bileschi ... Lucy J Colwell
    A machine learning model predicts the properties of proteins from their amino acid sequences and can run in a user's web browser.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Proteome-wide signatures of function in highly diverged intrinsically disordered regions

    Taraneh Zarin, Bob Strome ... Alan M Moses
    Widespread, rapidly evolving disordered regions contain molecular features that are preserved over evolution and are associated with specific biological functions.

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