A bnAb derived from a case of HIV superinfection has distinct qualities from other HIV-specific bnAbs, including framework residues that contribute to neutralization breadth and a unique viral escape profile.

Human antibodies that neutralize New World hantaviruses are promising for prevention or treatment of these high-priority emerging pathogens carried by rodents and transmitted to humans by aerosolized excreta or, in rare cases, person-to-person contact.

Machine learning identified six protective antibody features and showed for the first time that serological markers can predict protection from placental-malaria, which is important for evaluation and development of vaccines.

Structural and functional analysis of a new class of low-molecular-weight antibody fragments, derived from bovine immunoglobulins, reveals their therapeutic potential against C5, a target for refractory inflammatory diseases.

A fully synthetic library of humanized single domain antibodies yields in vitro high affinity antibodies usable in cell biology and translational projects.

Despite relative impermeability of the blood-brain barrier for calcitonin gene-related peptide antibodies used in migraine treatment, these antibodies induce certain and highly specific brain effects particularly in the hypothalamus which may be part of the mechanism of their efficacy.

Proteomics and functional genomics coupled to an antibody discovery pipeline revealed the influence of oncogenic RAS signaling on the cell-surface proteome and resulted in the discovery of potential therapeutic targets for RAS-driven cancers.

The absolute affinities of thousands of variant antibodies are measured in parallel using a combination of cell sorting and high-throughput DNA sequencing.

Modular tetravalent antibodies can be engineered to stimulate signaling through any combination of Frizzled and LRP receptors to drive organoid growth and mobilize endogenous stem cells in vivo.

HIV-specific antibodies that mediate antibody-dependent cellular cytotoxicity vary in their paths to achieve function but commonly rely on mutations in multiple regions, including framework regions, to reach full potency.