Tonic disinhibition of left motor cortex during prism adaptation enhanced consolidation of sensorimotor and cognitive prism after effects, causing lasting clinical gains in three patient cases with chronic treatment-resistant visual neglect.
A combined rehabitative protocol after stroke in the mouse normalizes transcallosal inhibition and promotes "true recovery" of forelimb motor function.
Christopher R Fetsch, Naomi N Odean ... Michael N Shadlen
Perceptual decision making in monkeys can be manipulated by using optogenetics to inactivate functional subregions of visual cortex, but the brain has a capacity to compensate for this perturbation.
Sean Froudist-Walsh, Philip GF Browning ... Paula L Croxson
Brain recovery after injury can be predicted based on its activity and structure, which may allow us to understand why some brain injuries lead to permanent loss of cognitive function, while others do not.
Thomas D Miller, Trevor T-J Chong ... Clive R Rosenthal
Human hippocampal cornu ammonis 3 damage impairs both recent and remote autobiographical episodic memory, and disrupts functional integration in medial temporal lobe subsystem regions of the default network.
Lesions to the anterior-medio-dorsal thalamus cause widespread behavioral impairments across multiple cognitive domains, suggesting that thalamic hubs are critical for interconnecting diverse cognitive processes.
Functional ultrasound imaging was used to monitor brain hemodynamics and sensory-evoked thalamocortical functions in awake rats pre- and post-stroke, advancing our understanding toward new therapeutic developments.