Convergent structural and functional brain deficits associated with dyslexia were found in left superior temporal gyrus across languages, however, language-specific deficits were also identified.
Systematic in vivo analysis reveals the divergent engagement of Plexin B structural motifs in distinct neurodevelopmental processes and a regulatory role of convertase cleavage in Plexin B signaling.
A gene duplication event has permitted the functional specialization of a homeodomain transcription factor through changes in exon-intron organization and these changes have supported the evolution of a major, phylum-level morphological novelty.
Pierre Khoueiry, Charles Girardot ... Eileen EM Furlong
Interspecies comparison of transcription factor occupancy during embryogenesis reveals potential co-operative relationships between factors and uncovers the inherent plasticity of developmental enhancers to overcome divergence in transcription factor occupancy.
Orthologous proteins that continuously maintain the same molecular function do not usually diverge beyond a certain level of sequence and structural similarity.
Lena Tveriakhina, Karin Schuster-Gossler ... Achim Gossler
Regions outside the major receptor binding interface of DLL1 and DLL4 contribute to context-dependent divergence of ligand function in vivo and differential Notch1 and Notch2 activation in vitro.
Meihua Christina Kuang, Paul D Hutchins ... Chris Todd Hittinger
Recent functional changes in ancient duplicate genes led to the evolution of divergent regulatory and metabolic strategies by the GALactose gene networks of two yeast species.
Children with ASD showed a significant divergence in gaze patterns compared to typically developing children, intensifying over early childhood, with implications for developmental and adaptive functioning.
A comparative analysis of human and chimpanzee polyadenylation site usage establishes alternative polyadenylation as another key mechanism underlying the genetic regulation of transcript and protein expression levels in primates.