2,528 results found
    1. Neuroscience

    Convergent and divergent brain structural and functional abnormalities associated with developmental dyslexia

    Xiaohui Yan, Ke Jiang ... Fan Cao
    Convergent structural and functional brain deficits associated with dyslexia were found in left superior temporal gyrus across languages, however, language-specific deficits were also identified.
    1. Developmental Biology
    2. Neuroscience

    Functional divergence of Plexin B structural motifs in distinct steps of Drosophila olfactory circuit assembly

    Ricardo Guajardo, David J Luginbuhl ... Jiefu Li
    Systematic in vivo analysis reveals the divergent engagement of Plexin B structural motifs in distinct neurodevelopmental processes and a regulatory role of convertase cleavage in Plexin B signaling.
    1. Developmental Biology
    2. Evolutionary Biology

    Functional divergence of paralogous transcription factors supported the evolution of biomineralization in echinoderms

    Jian Ming Khor, Charles A Ettensohn
    A gene duplication event has permitted the functional specialization of a homeodomain transcription factor through changes in exon-intron organization and these changes have supported the evolution of a major, phylum-level morphological novelty.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Uncoupling evolutionary changes in DNA sequence, transcription factor occupancy and enhancer activity

    Pierre Khoueiry, Charles Girardot ... Eileen EM Furlong
    Interspecies comparison of transcription factor occupancy during embryogenesis reveals potential co-operative relationships between factors and uncovers the inherent plasticity of developmental enhancers to overcome divergence in transcription factor occupancy.
    1. Evolutionary Biology

    Molecular function limits divergent protein evolution on planetary timescales

    Mariam M Konaté, Germán Plata ... Dennis Vitkup
    Orthologous proteins that continuously maintain the same molecular function do not usually diverge beyond a certain level of sequence and structural similarity.
    1. Developmental Biology

    The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro

    Lena Tveriakhina, Karin Schuster-Gossler ... Achim Gossler
    Regions outside the major receptor binding interface of DLL1 and DLL4 contribute to context-dependent divergence of ligand function in vivo and differential Notch1 and Notch2 activation in vitro.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation

    Hang Xu, Zihao Yuan ... Li Sun
    Functional divergence of caspase 3 and 7 in vertebrate is mediated by key residue mutation.
    1. Evolutionary Biology

    Ongoing resolution of duplicate gene functions shapes the diversification of a metabolic network

    Meihua Christina Kuang, Paul D Hutchins ... Chris Todd Hittinger
    Recent functional changes in ancient duplicate genes led to the evolution of divergent regulatory and metabolic strategies by the GALactose gene networks of two yeast species.
    1. Neuroscience

    Unraveling the developmental dynamic of visual exploration of social interactions in autism

    Nada Kojovic, Sezen Cekic ... Marie Schaer
    Children with ASD showed a significant divergence in gaze patterns compared to typically developing children, intensifying over early childhood, with implications for developmental and adaptive functioning.
    1. Genetics and Genomics

    Divergence in alternative polyadenylation contributes to gene regulatory differences between humans and chimpanzees

    Briana E Mittleman, Sebastian Pott ... Yoav Gilad
    A comparative analysis of human and chimpanzee polyadenylation site usage establishes alternative polyadenylation as another key mechanism underlying the genetic regulation of transcript and protein expression levels in primates.

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