4,405 results found
    1. Computational and Systems Biology
    2. Developmental Biology

    A human ESC-based screen identifies a role for the translated lncRNA LINC00261 in pancreatic endocrine differentiation

    Bjoern Gaertner et al.
    Ribosome profiling and loss-of-function during human ESC pancreatic differentiation reveal abundant lncRNA translation and an essential role for translated LINC00261 in beta cell differentiation, likely through a trans-regulatory, microprotein-independent mechanism.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    An analog to digital converter controls bistable transfer competence development of a widespread bacterial integrative and conjugative element

    Nicolas Carraro et al.
    A new multistep hierarchical cascade controls activation of an integrative and conjugative element in a small subpopulation of cells in its bacterial host, yielding proficient DNA transferring cells.
    1. Neuroscience

    Male-predominant galanin mediates androgen-dependent aggressive chases in medaka

    Junpei Yamashita et al.
    In medaka fish, galanin-expressing neurons in the medial preoptic area occur nearly exclusively in males and mediate androgen-dependent male–male aggressive chases.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Modeling the metabolic interplay between a parasitic worm and its bacterial endosymbiont allows the identification of novel drug targets

    David M Curran et al.
    A genome scale model of Brugia malayi metabolism illustrates a dynamic reliance on energy production pathways across its life cycle and identifies new drugs with experimentally supported anti-parasitic properties.
    1. Developmental Biology
    2. Immunology and Inflammation

    Estrogen exacerbates mammary involution through neutrophil-dependent and -independent mechanism

    Chew Leng Lim et al.
    Estrogen aggravates mammary involution through lysosome-mediated cell death, neutrophil recruitment via CXCR2 signalling, neutrophil-mediated inflammation and adipocyte repopulation.
    1. Developmental Biology
    2. Genetics and Genomics

    Odd-paired is a pioneer-like factor that coordinates with Zelda to control gene expression in embryos

    Theodora Koromila et al.
    The gene Odd-paired is a late-acting regulator of zygotic gene expression, functioning coordinately with Zelda to influence chromatin accessibility and affecting genes expressed along both axes of Drosophila embryos.
    1. Cell Biology
    2. Immunology and Inflammation

    Mouse T cell priming is enhanced by maturation-dependent stiffening of the dendritic cell cortex

    Daniel Blumenthal et al.
    The dendritic cell actin cytoskeleton provides a platform for T cell mechanosensing, delivering novel biophysical cues that serve as costimulatory signals for T cell activation.

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