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    1. Evolutionary Biology
    2. Genetics and Genomics

    Drought adaptation in Arabidopsis thaliana by extensive genetic loss-of-function

    J Grey Monroe et al.
    Gene knockouts provide valuable genetic fuel for climate adaptation in nature.
    1. Ecology
    2. Genetics and Genomics

    The Natural History of Model Organisms: The fascinating and secret wild life of the budding yeast S. cerevisiae

    Gianni Liti
    The yeast Saccharomyces cerevisiae has informed our understanding of molecular biology and genetics for decades, and learning more about its natural history could fuel a new era of functional and evolutionary studies of this classic model organism.
    1. Genetics and Genomics
    2. Human Biology and Medicine

    Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis

    Satish K Nandakumar et al.
    A gene-centric functional screen uncovers biological mechanisms underlying genome-wide association study signals for human red blood cell traits.
    1. Neuroscience

    The heritability of multi-modal connectivity in human brain activity

    Giles L Colclough et al.
    Genes play an important role in determining the strength of functional connectivity in the human brain, and seem to outweigh the contribution from the developmental environment.
    1. Evolutionary Biology

    Subterranean mammals show convergent regression in ocular genes and enhancers, along with adaptation to tunneling

    Raghavendran Partha et al.
    Repeated evolution of eye regression in subterranean mammals helps identify genes and regulatory elements involved in visual perception and development of the eye, and predicts candidate sequences with a potential role in ocular disorders.
    1. Developmental Biology
    2. Evolutionary Biology

    Complex transcriptional regulation and independent evolution of fungal-like traits in a relative of animals

    Alex de Mendoza et al.
    Functional genomics reveal complex genome regulation during the coenocytic development of the ichthyosporean Creolimax fragrantissima, a protist closely related to animals.
    1. Microbiology and Infectious Disease

    Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni

    Wannaporn Ittiprasert et al.
    Gene knock-out of the omega-1 ribonuclease of Schistosoma mansoni eggs resulted in immunologically impaired phenotype, showcasing the novel application of CRISPR/Cas9 genome editing and utility for functional genomics in schistosomes.
    1. Cell Biology
    2. Immunology and Inflammation

    Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions

    Alejandro Villarino et al.
    Asymmetrical expression dictates functional dominance of one STAT5 paralog at cellular and tissue levels despite redundancy at molecular and genomic levels.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation

    Daniil Alpern et al.
    Physical and functional interactions between HNF4A and TAF4 coordinate HNF4A genomic occupancy with pre-initiation complex formation to activate post-natal hepatocyte gene expression.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Individual long non-coding RNAs have no overt functions in zebrafish embryogenesis, viability and fertility

    Mehdi Goudarzi et al.
    Defining the biological functions of long non-coding RNAs, individually or as a class, and teasing apart the role of underlying genomic sequences remains the biggest challenge for this field.