4,958 results found
    1. Cell Biology

    Cell Biology: New twists in the unfolded protein response

    Benedict C S Cross, David Ron
    Version of Record
    Insight
    1. Structural Biology and Molecular Biophysics

    Molecular architecture of human polycomb repressive complex 2

    Claudio Ciferri, Gabriel C Lander ... Eva Nogales
    Electron microscopy has been used to produce the first three-dimensional image of the PRC2 gene-silencing complex.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

    Huan Yan, Guocai Zhong ... Wenhui Li
    Biochemical and genetic tests have revealed that a liver protein called NTCP is a functional receptor for hepatitis B and D viruses, which should lead to an improved understanding of the infections caused by these viruses and assist the development of new intervention strategies.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Elba, a novel developmentally regulated chromatin boundary factor is a hetero-tripartite DNA binding complex

    Tsutomu Aoki, Ali Sarkeshik ... Paul Schedl
    A chromatin boundary factor that is only active during early embryo development has been discovered in Drosophila.
    1. Biochemistry and Chemical Biology

    RecA filament sliding on DNA facilitates homology search

    Kaushik Ragunathan, Cheng Liu, Taekjip Ha
    A DNA–protein complex can find target sequences of bases in another DNA molecule by sliding along it.
    1. Cell Biology
    2. Evolutionary Biology

    Chromatin is an ancient innovation conserved between Archaea and Eukarya

    Ron Ammar, Dax Torti ... Corey Nislow
    Similarities in the way that nucleosomes are organized into chromatin in archaea and eukaryotes suggest that chromatin might have been involved in gene regulation before its role in DNA packaging evolved.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Meiosis I chromosome segregation is established through regulation of microtubule–kinetochore interactions

    Matthew P Miller, Elçin Ünal ... Angelika Amon
    Preventing premature interactions between microtubules and protein-based structures called kinetochores ensures that chromosomes are segregated by meiosis rather than mitosis in reproductive cells.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure

    Taesun Eom, Chaolin Zhang ... Robert B Darnell
    The HITS-CLIP sequencing method is used to demonstrate that cryptic exons can detect messenger RNA that contains nonsense mutations, and then cause this RNA to decay, which shows that these exons are involved in maintaining the electrical balance of neurons and, possibly, preventing epilepsy.

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