Genetic and molecular analyses reveal the decisive role of fatty acid oxidation (FAO) acting downstream to the ROS-JNK circuit essential for hemocyte progenitor differentiation in Drosophila..
The interplay of recurrent excitation and short-term plasticity enables nonlinear transient amplification, an ideal mechanism for selective amplification, pattern completion, and pattern separation in recurrent neural networks.
Nanoscaleimaging reveals that animal septins form dense filamentous networks on biomimeticlipid membranes, explaining how septins may regulate cell surface rigidity.
The fossil record of abdominal modifications in male scorpionflies documents a relatively late evolution of oppressive behaviour toward a female during mating and suggest degree of sexual coercion greater in Eocene than in any other known scorpionfly, extinct or extant.
Lucas M Walker, James RJ Haycocks ... David C Grainger
Overlapping DNA-binding specificity allows global transcription factors to cooperatively bind the same DNA sites and integrate two signals in the control of gene expression.
Nurul Jannah Mohamed Nasir, Hans Heemskerk ... Lisa Tucker-Kellogg
Myoglobin iron contributes to the formation and poor healing of muscle pressure injuries, that is, bedsores, and iron-chelation therapy can be administered after prolonged pressure to increase survival of the damaged tissue.
Silvia Cardani, Tara A Janes ... Silvia Pagliardini
Knockdown of PHOX2B in the chemosensitive area of the retrotrapezoid nucleus of adult rats reduces CO2 responses and the expression of the proton sensors TASK2 and GPR4.
Karin Purshouse, Elias T Friman ... Wendy A Bickmore
In glioblastoma stem cells, oncogenes on extrachromosomal DNA do not cluster at distances in keeping with coordinated transcription, with amplified gene expression driven by copy number rather increased transcriptional efficiency.
Cryo-EM analysis of full-length human epidermal growth factor receptor provides a molecular explanation for how ligand-induced differential effect in the ligand-binding extracellular module tunes the transmembrane signaling mediated by epidermal growth factor receptor.
Salman Shehzada, Tomoko Noto ... Kazufumi Mochizuki
The identification of a SUMO E3 ligase engaged in lncRNA transcription, subsequently leading to target-directed small RNA degradation, reveals an unexplored layer of regulatory mechanisms within small RNA-directed chromatin regulation.
