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    1. Biochemistry and Chemical Biology

    Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function

    Susanne Gerndt et al.
    The lysosomal ion channel TPC2 emerges as an example of an ion channel in which ion selectivity is not fixed but rather agonist-selective.
    1. Neuroscience

    Categorical representation from sound and sight in the ventral occipito-temporal cortex of sighted and blind

    Stefania Mattioni et al.
    The categorical organization of the ventral occipito-temporal cortex, typically thought to be a visual region, is actually partially independent of visual input and even visual experience.
    1. Genetics and Genomics

    Characterising a healthy adult with a rare HAO1 knockout to support a therapeutic strategy for primary hyperoxaluria

    Tracy L McGregor et al.
    Lifelong HAO1 knockout was safe and without clinical phenotype in an identified healthy woman, de-risking a rare disease therapeutic approach through the power of naturally occurring human genetic variation.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    The Cryo-EM structure of pannexin 1 reveals unique motifs for ion selection and inhibition

    Kevin Michalski et al.
    The structure of a pannexin 1 uncovers the extracellular loops of pannexin 1 as important structural motifs for ion selectivity and channel inhibition.
    1. Neuroscience

    Visually-updated hand state estimates modulate the proprioceptive reflex independently of motor task requirements

    Sho Ito, Hiroaki Gomi
    Distortion and elimination of limb visual feedback affects low-level stretch reflex control, indicating the involvement of a high-level and multimodal representation of the limb state in orchestrating hierarchical sensorimotor control.
    1. Cell Biology
    2. Developmental Biology

    Fibronectin is a smart adhesive that both influences and responds to the mechanics of early spinal column development

    Emilie Guillon et al.
    A fibronectin matrix constantly remodels to the area of highest mechanical stress, and the resulting fibronectin-mediated inter-tissue adhesion impedes neural tube convergence.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Ion Channels: Taking a close look at a large-pore channel

    Pablo S Gaete, Jorge E Contreras
    The structure of pannexin 1, a channel protein with a large pore, has been determined for the first time.
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    1. Developmental Biology

    Mononuclear diploid cardiomyocytes support neonatal mouse heart regeneration in response to paracrine IGF2 signaling

    Hua Shen et al.
    Neonatal mouse heart regeneration relies on the presence of mononuclear diploid cardiomyocytes, which unites this process with embryonic heart growth and adult heart regeneration.
    1. Developmental Biology
    2. Neuroscience

    Extracellular matrix-inducing Sox9 promotes both basal progenitor proliferation and gliogenesis in developing neocortex

    Ayse Güven et al.
    Transcription factor Sox9 has an important role in neocortex expansion, where its expression in basal progenitors increases proliferation, induces premature gliogenesis and promotes the expression of extracellular matrix components.
    1. Cell Biology
    2. Neuroscience

    The membrane periodic skeleton is an actomyosin network that regulates axonal diameter and conduction

    Ana Rita Costa et al.
    The axonal cytoskeletal contains an actomyosin-II network that controls circumferential axonal contraction and expansion with the potential of regulating fluctuations in diameter during action potential firing, trafficking, and degeneration.