5,308 results found
    1. Structural Biology and Molecular Biophysics
    2. Human Biology and Medicine

    Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation

    Sean W Fanning et al.
    Two common mutant versions of estrogen receptor alpha achieve constitutive activity and hormone-resistance by preferentially adopting a suite of conformations that expose the coregulator-binding surface.
  1. Point of View: The NIH must reduce disparities in funding to maximize its return on investments from taxpayers

    Wayne P Wahls
    A more balanced distribution of NIH grant funding among investigators would strengthen the diversity of the research enterprise, increase the likelihood of scientific breakthroughs, and lead to a greater return on taxpayers' investments.
    1. Cell Biology

    Recruitment dynamics of ESCRT-III and Vps4 to endosomes and implications for reverse membrane budding

    Manuel Alonso Y Adell et al.
    Quantitative 3D lattice light sheet microscopy of unperturbed cells combined with electron tomography and acute loss of function experiments reveals how dynamic ESCRT-III/Vps4 assemblies succeed in reverse membrane budding on endosomes.
    1. Neuroscience

    Organization and function of Drosophila odorant binding proteins

    Nikki K Larter et al.
    A genetic analysis reveals that some olfactory sensilla of Drosophila do not require an abundant odorant binding protein and that one such protein may act in gain control.
    1. Neuroscience

    Hunger neurons drive feeding through a sustained, positive reinforcement signal

    Yiming Chen et al.
    Hunger neurons promote feeding by triggering a long-lasting potentiation of the rewarding properties of food.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR

    Simon Erlendsson et al.
    Solid state NMR is unable to detect any association of substrate to the second binding site, S2, in the extracellular vestibule of the Neurotransmitter:Sodium Symporter LeuT.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Conservation of transcription factor binding specificities across 600 million years of bilateria evolution

    Kazuhiro R Nitta et al.
    Drosophila has almost all transcription factor binding specificities available to humans; and human transcription factors with divergent specificities operate in cell types that are not found in fruit flies.
    1. Neuroscience

    An opioid-like system regulating feeding behavior in C. elegans

    Mi Cheong Cheong et al.
    The discovery that opioid neuropeptide neuronal signaling controls feeding behavior in a genetically tractable invertebrate model may help unravel the mechanisms of appetite control in humans.
    1. Biochemistry and Chemical Biology

    Translation repression via modulation of the cytoplasmic poly(A)-binding protein in the inflammatory response

    Xu Zhang et al.
    The RNA-binding protein, Zfp36, which is critical for resolving inflammation, inhibits the production of proinflammatory cytokines via modulation of the cytoplasmic poly(A)-binding protein.
    1. Neuroscience

    Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106

    Barbara Celona et al.
    Zfp106 functions as an RNA binding protein, binds directly to GGGGCC RNA repeats, is required in motor neurons to prevent ALS-like neurodegeneration in mice, and can suppress neurotoxicity in an established fly model of ALS.

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