63 results found
    1. Computational and Systems Biology

    Longitudinal fundus imaging and its genome-wide association analysis provide evidence for a human retinal aging clock

    Sara Ahadi, Kenneth A Wilson ... Ali Bashir
    Deep learning on fundus images provides a non-invasive, short time-scale biological aging clock that successfully identifies aging genes validated in a fly model.
    1. Neuroscience

    Functionally defined white matter of the macaque monkey brain reveals a dorso-ventral attention network

    Ilaria Sani, Brent C McPherson ... Winrich A Freiwald
    Primate attention is not limited to a dorsal fronto-parietal network, but includes a ventral temporal node and its dorso-ventral interactions with other attentional areas.
    1. Cell Biology
    2. Neuroscience

    Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies

    Wei-Hua Lee, Hitoshi Higuchi ... Akihiro Ikeda
    The murine protein TMEM135 is a critical link between aging and age-dependent diseases.
    1. Neuroscience

    Preserved extrastriate visual network in a monkey with substantial, naturally occurring damage to primary visual cortex

    Holly Bridge, Andrew H Bell ... Kristine Krug
    Even when the primary visual cortical area is absent bilaterally from early life, the rest of a primate visual brain can develop and function normally to support day-to-day visual behaviour.
    1. Neuroscience

    Multi-scale mapping along the auditory hierarchy using high-resolution functional UltraSound in the awake ferret

    Célian Bimbard, Charlie Demene ... Yves Boubenec
    Functional UltraSound imaging allows mapping tonotopic organisation in multiple auditory subcortical and cortical brain structures with an unprecedented spatial functional resolution, while giving access to long-distance top-down connectivity pattern from frontal cortex to auditory cortex.
    1. Neuroscience

    Disturbed retinoid metabolism upon loss of rlbp1a impairs cone function and leads to subretinal lipid deposits and photoreceptor degeneration in the zebrafish retina

    Domino K Schlegel, Srinivasagan Ramkumar ... Stephan CF Neuhauss
    The retinoid-binding protein RLBP1 in the retinal pigment epithelium is crucially involved in cone photoreceptor visual pigment recycling and mimics the human eye disease with retinal lipid deposits when mutated.
    1. Neuroscience

    Chimpanzee brain morphometry utilizing standardized MRI preprocessing and macroanatomical annotations

    Sam Vickery, William D Hopkins ... Felix Hoffstaedter
    Openly available structural imaging processing pipeline for chimpanzees including registration templates and macro-anatomical parcellation shows human-like cerebral aging and medial hemispheric organization.
    1. Neuroscience

    Anatomy of nerve fiber bundles at micrometer-resolution in the vervet monkey visual system

    Hiromasa Takemura, Nicola Palomero-Gallagher ... Karl Zilles
    Polarized light imaging demonstrates detailed organization of projection, callosal, longitudinal association and short association fibers in the primate visual system at micrometer-resolution.
    1. Immunology and Inflammation

    A novel role for lipoxin A4 in driving a lymph node–eye axis that controls autoimmunity to the neuroretina

    Jessica Wei, Mary J Mattapallil ... Rachel R Caspi
    LXA4 in lymph nodes is an important resident homeostatic regulator that controls effector T cell functions and egress in the development of adaptive immune responses.
    1. Neuroscience

    Cytoarchitectonic, receptor distribution and functional connectivity analyses of the macaque frontal lobe

    Lucija Rapan, Sean Froudist-Walsh ... Nicola Palomero-Gallagher
    3D atlas of the macaque frontal lobe, based on the novel quantitative parcellation, integrates anatomical, neurochemical, and functional connectivity data.

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