138 results found
    1. Epidemiology and Global Health

    Standardized mean differences cause funnel plot distortion in publication bias assessments

    Peter-Paul Zwetsloot, Mira Van Der Naald ... Kimberley E Wever
    Funnel plots of the Standardized Mean Difference versus the standard error are prone to distortion, leading to false-positive tests for funnel plot asymmetry, and therefore using the Normalised Mean Difference, or a sample size-based precision estimate, are more reliable alternatives.
    1. Ecology

    Meta-analysis challenges a textbook example of status signalling and demonstrates publication bias

    Alfredo Sánchez-Tójar, Shinichi Nakagawa ... Julia Schroeder
    Meta-analysis takes down a textbook example in behavioural and evolutionary ecology, and demonstrates the existence of biases in the current scientific publishing culture.
    1. Neuroscience

    Meta-Research: Lessons from a catalogue of 6674 brain recordings

    Alexis DJ Makin, John Tyson-Carr ... Marco Bertamini
    A complete public catalogue of brain recording data from a single laboratory has revealed new scientific findings, and has also shed light on aspects of the scientific process, such as statistical power and publication bias.
    1. Epidemiology and Global Health
    2. Medicine

    Direct economic burden of mental health disorders associated with polycystic ovary syndrome: Systematic review and meta-analysis

    Surabhi Yadav, Olivia Delau ... Ricardo Azziz
    Polycystic ovary syndrome (PCOS) is a highly prevalent disorder of women, with significant reproductive, endocrine, and metabolic morbidities and a total healthcare-related economic burden exceeding $15 billion (2021 USD) for the U.S. alone, $4 billion due to mental health disorders.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Mendelian randomization suggests a bidirectional, causal relationship between physical inactivity and adiposity

    Germán D Carrasquilla, Mario García-Ureña ... Tuomas O Kilpeläinen
    Bidirectional causal relationship between higher sedentary time and higher adiposity suggests that decreasing sedentary time is beneficial for weight management, but also that weight loss may help reduce sedentary time.
    1. Epidemiology and Global Health
    2. Medicine

    Evaluating mesenchymal stem cell therapy for sepsis with preclinical meta-analyses prior to initiating a first-in-human trial

    Manoj M Lalu, Katrina J Sullivan ... Lauralyn McIntyre
    A rigorous and transparent evaluation of mesenchymal stem cell therapy for sepsis suggests it may be efficacious, although the strength of these findings is tempered by threats to validity in the studies that were included.
    1. Ecology
    2. Epidemiology and Global Health

    Landscape drives zoonotic malaria prevalence in non-human primates

    Emilia Johnson, Reuben Sunil Kumar Sharma ... Kimberly Fornace
    Regional meta-analysis enriches our understanding of zoonotic malaria in primate reservoirs in areas of Southeast Asia experiencing deforestation, with wider ecological implications for human disease risk in fragmented landscapes.
    1. Evolutionary Biology

    A meta-analysis of the association between male dimorphism and fitness outcomes in humans

    Linda H Lidborg, Catharine Penelope Cross, Lynda G Boothroyd
    While men’s mating success is predicted both by their strength/muscularity, voice pitch, height, and testosterone levels, their reproductive output is only predicted by strength/muscularity.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure and transport mechanism of the sodium/proton antiporter MjNhaP1

    Cristina Paulino, David Wöhlert ... Werner Kühlbrandt
    The inward-open and outward-open structures of MjNhaP1 explain the mechanism of electroneutral sodium-proton antiport across the cell membrane.
    1. Physics of Living Systems

    Origin and role of the cerebrospinal fluid bidirectional flow in the central canal

    Olivier Thouvenin, Ludovic Keiser ... Claire Wyart
    The combination of data and modelling shows the mechanisms underlying bidirectional flow of cerebrospinal fluid and its impact on long range transport in the CSF between brain and spinal cord.

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