4,936 results found
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Linking plasmid-based beta-lactamases to their bacterial hosts using single-cell fusion PCR

    Peter J Diebold et al.
    One-step Isolation and Lysis (OIL) PCR offers a robust, versatile, accessible, and high-throughput method for linking mobile DNA with bacterial hosts in natural microbial communities.
    1. Cell Biology

    TANGO1 recruits ERGIC membranes to the endoplasmic reticulum for procollagen export

    António JM Santos et al.
    Building on previous work (Nogueira et al., 2014), we describe a mechanism for the generation of a mega-carrier for the export of bulky procollagen from the endoplasmic reticulum.
    1. Genetics and Genomics

    Quiescence unveils a novel mutational force in fission yeast

    Serge Gangloff et al.
    The quiescence-driven mutational landscape reveals replication-independent mutagenesis as a novel evolutionary force.
    1. Cell Biology

    Pericentrin-mediated SAS-6 recruitment promotes centriole assembly

    Daisuke Ito et al.
    Newly discovered interaction between fission yeast SPB and animal centriole components reveals that pericentrin not only functions as a microtubule-nucleator, but also promotes centriole assembly in animals.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Dilation of fusion pores by crowding of SNARE proteins

    Zhenyong Wu et al.
    A few SNARE complexes suffice to fuse membranes, but many more are needed to dilate the nascent fusion pore by molecular crowding for efficient neurotransmitter or hormone release during exocytosis.
    1. Neuroscience

    Sensitivity and kinetics of signal transmission at the first visual synapse differentially impact visually-guided behavior

    Ignacio Sarria et al.
    Adjusting key parameters of the synaptic transmission at a single defined synapse of the visual circuit can affect properties of this circuit and animal behavior.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Cooperative and acute inhibition by multiple C-terminal motifs of L-type Ca2+ channels

    Nan Liu et al.
    C-terminus mediated inhibition is one emerging modality of intervention for L-type Ca2+ channels, which coordinate multiple motifs to acutely tune Ca2+ current and Ca2+ influx down to the lower limits preset by end-stage Ca2+-dependent inactivation.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    A new view of transcriptome complexity and regulation through the lens of local splicing variations

    Jorge Vaquero-Garcia et al.
    New methods reveal that complex local splicing variations are more prevalent in animals than previously appreciated, and demonstrate that local splicing variations are relevant for studies of development, gene regulation and neurodegenerative diseases.
    1. Structural Biology and Molecular Biophysics
    2. Developmental Biology

    Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan

    Tao-Hsin Chang et al.
    The crystal structure of Norrie Disease Protein in complex with the extracellular cysteine-rich domain of Frizzled4 receptor and sucrose octasulfate reveals binding sites for Frizzled4, low density lipoprotein receptor related protein 5/6, and proteoglycan.
    1. Cell Biology

    Reconstruction of Par-dependent polarity in apolar cells reveals a dynamic process of cortical polarization

    Kalyn Kono et al.
    Par-complex-dependent cell polarity can be cell-autonomously conferred to non-polar Drosophila S2 cells, unveiling temporal patterns toward the cortical localization of Par-complex aggregates that include a meshwork containing unit segments.

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