Accurate identification and quantification of various circRNA isoforms.

Cardiovascular disease, the top cause of diabetic deaths, progresses via vascular endothelial dysfunction, with circHMGCS1 and miR4521 highlighted as potential markers for the development of this condition.

In the context of SARS-CoV-2 infection, Nsp14 alters gene expression of the host cell through the interaction with the cellular enzyme IMPDH2.

Non-coding RNAs appear to be good candidates as biomarkers for predicting treatment response and therapeutics for sarcoma, their differential expression across tissues complicates their application.

Biochemical tags can be easily knocked into endogenous genes in mammalian stem cells using optimised and scalable protocols that will enable annotation of protein levels, localisation and interaction partners.

Many bacteria use the Nus factor antitermination complex to prevent premature Rho-dependent transcription termination of their CRISPR arrays.

Cas12a CRISPR arrays are sensitive to the GC content of their spacers, but AT-rich separator sequences successfully remove this disruptive effect and enable enhanced multiplexed gene targeting and activation.

Cooperation between evolutionarily disparate CRISPR-Cas modules allows bacteria to counter mutational escape by viruses.

A truncated, non-signaling insulin receptor regulates insulin sensitivity in the nematode C. elegans by sequestering insulin peptides and preventing their interaction with full length receptors.

Modulating the nutrient sensor TORC1 only in neurons in C. elegans is sufficient to regulate systemic longevity via inter-tissue signals that remodel mitochondria networks in non neuronal cells.