4,540 results found
    1. Ecology
    2. Evolutionary Biology

    Understanding the evolution of multiple drug resistance in structured populations

    David V McLeod, Sylvain Gandon
    The evolution of multidrug resistance can be most easily understood by focusing upon the dynamical equations of linkage disequilibrium.
    1. Physics of Living Systems
    2. Cell Biology

    Mechanical heterogeneity along single cell-cell junctions is driven by lateral clustering of cadherins during vertebrate axis elongation

    Robert J Huebner et al.
    Very local molecular patterns impart precise changes in the local mechanics of individual cell-cell junctions.
    1. Cell Biology

    Kinesin-6 Klp9 orchestrates spindle elongation by regulating microtubule sliding and growth

    Lara Katharina Krüger et al.
    During anaphase B spindle elongation, Klp9 controls the speed of both microtubule sliding and microtubule growth to coordinate the processes and thus maintain spindle stability for faithful chromosome separation.
    1. Evolutionary Biology

    Myoglobin primary structure reveals multiple convergent transitions to semi-aquatic life in the world's smallest mammalian divers

    Kai He et al.
    Ancestral sequence reconstruction of an essential muscle protein involved in O2 storage and transport accurately tracks secondary aquatic transitions in a speciose clade of insectivorous mammals.
    1. Computational and Systems Biology
    2. Developmental Biology

    Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration

    Emanuel Cura Costa et al.
    Computational modeling and a cell cycle-reporting axolotl reveal how spinal cord regeneration can be achieved by a signal that propagates 828 μm from the injury site during the first 85 hours post-amputation.
    1. Genetics and Genomics
    2. Medicine

    Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning

    Yi Liu et al.
    Systematic quantification of abdominal organ health parameters using deep learning generates new insights into the genetic architecture of cardiometabolic health traits.
    1. Cell Biology
    2. Medicine

    Tetrahydroxanthohumol, a xanthohumol derivative, attenuates high-fat diet-induced hepatic steatosis by antagonizing PPARγ

    Yang Zhang et al.
    Identifying xanthohumol and its derivatives as PPARγ anatagonists provides new insight into how natural compounds beneficially treat obesity and metabolic syndrome, and provide new compounds for therapeutic development.
    1. Biochemistry and Chemical Biology

    Dwarf open reading frame (DWORF) is a direct activator of the sarcoplasmic reticulum calcium pump SERCA

    M'Lynn E Fisher et al.
    Activation of the sarcoplasmic reticulum calcium pump and enhancement of cellular calcium homeostasis by dwarf open reading frame reveal how this small membrane protein opposes phospholamban inhibitory function in cardiac muscle.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Repression by the Arabidopsis TOPLESS corepressor requires association with the core mediator complex

    Alexander R Leydon et al.
    The TPL corepressor binds to the core mediator complex through MED21 to inhibit transcription while simultaneously priming repressed genes for rapid reactivation.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Single-PanIN-seq unveils that ARID1A deficiency promotes pancreatic tumorigenesis by attenuating KRAS-induced senescence

    Shou Liu et al.
    ARID1A deficiency in SWI/SNF complex promotes pancreatic tumor development by upregulating ALDH protein levels to effectively reduce cellular reactive oxygen species levels, leading to the significant attenuation of oncogenic KRAS-induced senescence.

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