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    1. Neuroscience

    Value signals guide abstraction during learning

    Aurelio Cortese et al.
    Valuation of sensory information in the ventromedial prefrontal cortex plays a key function in constructing the abstract representations that guide complex behaviours.
    1. Epidemiology and Global Health

    Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset

    Ariel Karlinsky, Dmitry Kobak
    The World Mortality Dataset and paper is the largest dataset of all-cause mortality currently in existence for tracking mortality and excess mortality during the COVID-19 pandemic.
    1. Cell Biology
    2. Neuroscience

    Pharmacological rescue of impaired mitophagy in Parkinson’s disease-related LRRK2 G2019S knock-in mice

    Francois Singh et al.
    The most common Parkinson’s disease-associated mutation, LRRK2 G2019S, impairs mitophagy in clinically relevant cells within the mouse brain and this defect can be reversed using a novel LRRK2 inhibitor.
    1. Neuroscience

    The role of ventromedial prefrontal cortex in reward valuation and future thinking during intertemporal choice

    Elisa Ciaramelli et al.
    During decisions between smaller-immediate rewards and larger rewards available in the future, the ventromedial prefrontal cortex is critical to represent the value of rewards, not the future.
    1. Biochemistry and Chemical Biology

    Instability in NAD+ metabolism leads to impaired cardiac mitochondrial function and communication

    Knut H Lauritzen et al.
    Transgenic mice and cell models provide evidence of a pathophysiological mechanism that connects mtDNA damage to cardiac dysfunction via reduced NAD+ levels and loss of mitochondrial function and communication.
    1. Cell Biology

    Different translation dynamics of β- and γ-actin regulates cell migration

    Pavan Vedula et al.
    β- and γ-cytoplasmic actins have different translation rates in cells and exert different nucleotide coding sequence-dependent effects on cell migration.
    1. Neuroscience

    Tracking the relation between gist and item memory over the course of long-term memory consolidation

    Tima Zeng et al.
    Human learners’ memory for generalities across individual items biased memory for these items after 1 month.
    1. Neuroscience

    Interpreting wide-band neural activity using convolutional neural networks

    Markus Frey et al.
    A novel deep-learning framework shows how to interpret and decode raw neural recordings, avoiding the need for strong prior hypotheses, revealing a novel representation of head direction.
    1. Cell Biology

    CDK1 controls CHMP7-dependent nuclear envelope reformation

    Alberto T Gatta et al.
    CHMP7 is phosphorylated by CDK1 upon mitotic entry, preventing interaction with LEM2 and inappropriate assembly during mitotic exit.
    1. Neuroscience

    Unsupervised changes in core object recognition behavior are predicted by neural plasticity in inferior temporal cortex

    Xiaoxuan Jia et al.
    Temporal continuity-induced plasticity in individual neurons of inferior temporal cortex builds neural representations that underlie robust core object recognition behavior.