136 results found
    1. Neuroscience

    POMC neurons control fertility through differential signaling of MC4R in Kisspeptin neurons

    Rajae Talbi, Todd L Stincic ... Víctor M Navarro
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Cell Biology

    Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis

    Joan Chang, Adam Pickard ... Karl E Kadler
    Secretion and fibrillogenesis of collagen-I are separately controlled molecular pathways in the fibroblast, where surprisingly endocytic recycling is required for fibril formation and is increased in fibrotic fibroblasts.
    1. Cancer Biology

    Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation

    Trang H Pham, Kanika Bajaj Pahuja ... Anwesha Dey
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Hidden GPCR structural transitions addressed by multiple walker supervised molecular dynamics (mwSuMD)

    Giuseppe Deganutti, Ludovico Pipitò ... Christopher A Reynolds
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Genetics and Genomics

    Maf-family bZIP transcription factor NRL interacts with RNA-binding proteins and R-loops in retinal photoreceptors

    Ximena Corso-Díaz, Xulong Liang ... Anand Swaroop
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Predictably manipulating photoreceptor light responses to reveal their role in downstream visual responses

    Qiang Chen, Norianne T Ingram ... Fred Rieke
    Quantitative models for responses of rod and cone photoreceptors are developed that allow direct tests of the impact of the photoreceptors on responses of downstream visual neurons.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Insights into early animal evolution from the genome of the xenacoelomorph worm Xenoturbella bocki

    Philipp H Schiffer, Paschalis Natsidis ... Maximilian J Telford
    A genome analysis of Xenoturbella bocki provides insights into the biology of this enigmatic marine worm and enhances our understanding of early bilaterian evolution.
    1. Neuroscience

    Robust optogenetic inhibition with red-light-sensitive anion-conducting channelrhodopsins

    Johannes Oppermann, Andrey Rozenberg ... Peter Hegemann
    Engineered anion-conducting channelrhodopsins with enhanced red-light sensitivity and accelerated kinetics enable precise, low-intensity optical silencing of neurons, advancing optogenetic control in neuroscience research.

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