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    1. Chromosomes and Gene Expression

    GAF is essential for zygotic genome activation and chromatin accessibility in the early Drosophila embryo

    Marissa M Gaskill et al.
    Following fertilization, the pioneering transcription factors GAGA factor (GAF) and Zelda are independently required to reprogram the zygotic genome of Drosophila and activate the first wave of gene expression.
    1. Neuroscience

    Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation

    André M Bastos et al.
    Understanding how general anesthesia changes neural dynamics in the cortex and thalamus can lead to its safer use and shed light on the nature of consciousness.
    1. Neuroscience

    Impaired spatial learning and suppression of sharp wave ripples by cholinergic activation at the goal location

    Przemyslaw Jarzebowski et al.
    Elevated cholinergic activity disrupts offline hippocampal state and impairs memory formation highlighting the need for a precise timing of cholinergic activity in learning and memory.
    1. Physics of Living Systems

    Ligand sensing enhances bacterial flagellar motor output via stator recruitment

    Farha Naaz et al.
    Sensing of ligands by chemoreceptors of Escherichia coli not only causes changes in the rotational bias of the flagellar motors but also increases motor speed via temporary recruitment of stators.
    1. Developmental Biology
    2. Immunology and Inflammation

    Identification of functionally distinct macrophage subpopulations in Drosophila

    Jonathon Alexis Coates et al.
    Drosophila macrophages are a heterogeneous population of cells containing subpopulations with enhanced responses to injury that display considerable variation in their abundance across development.
    1. Immunology and Inflammation

    Intravital quantification reveals dynamic calcium concentration changes across B cell differentiation stages

    Carolin Ulbricht et al.
    Heterogeneity in cytoplasmic calcium concentration alongside B cell activation and differentiation is measured intravitally using an interdisciplinary imaging approach and novel numerical analysis.
    1. Genetics and Genomics

    Genetic association and causal inference converge on hyperglycaemia as a modifiable factor to improve lung function

    William R Reay et al.
    Genetic data revealed existing drugs that could be repurposed to improve lung function, with evidence that compounds which control blood glucose could be particularly useful for respiratory impairment.
    1. Neuroscience

    Relationship between simultaneously recorded spiking activity and fluorescence signal in GCaMP6 transgenic mice

    Lawrence Huang et al.
    Simultaneous calcium imaging and cell-attached recording in GCaMP6 transgenic mice in vivo reveals spiking-fluorescence relationship that supports more refined inference of neuronal activities from calcium imaging data.
    1. Neuroscience

    Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner

    Kang-Ying Qian et al.
    Male pheromone environment increases the cholinergic synaptic transmission at the neuromuscular junction in Caenorhabditis elegans hermaphrodites during development, decreasing hermaphrodites' locomotion activity and promoting mating efficiency.