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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Reciprocal regulation among TRPV1 channels and phosphoinositide 3-kinase in response to nerve growth factor

    Anastasiia Stratiievska et al.
    A dual-color TIRFM study reveals a new form of inflammatory regulation, in which a lipid kinase and ion channel reciprocally regulate each other to amplify the response to painful stimuli.
    1. Evolutionary Biology

    Geological and taphonomic context for the new hominin species Homo naledi from the Dinaledi Chamber, South Africa

    Paul HGM Dirks et al.
    A new hominin species found in a South African cave is part of one of the most unusual hominin fossil assemblages on record.
    1. Developmental Biology
    2. Neuroscience

    Imp/IGF2BP levels modulate individual neural stem cell growth and division through myc mRNA stability

    Tamsin J Samuels et al.
    Single molecule mRNA imaging uncovers post-transcriptional regulation of myc mRNA, via a cell-intrinsic mechanism allowing individualised control of neural stem cell proliferation during Drosophila brain development.
    1. Cell Biology
    2. Genetics and Genomics

    Micronuclei-based model system reveals functional consequences of chromothripsis in human cells

    Maja Kneissig et al.
    A method to generate human cells with massive chromosomal aberrations on a specific chromosome allows analysis of their consequences.
    1. Genetics and Genomics
    2. Neuroscience

    The ion channel ppk301 controls freshwater egg-laying in the mosquito Aedes aegypti

    Benjamin J Matthews et al.
    The ion channel ppk301 is required for the evaluation of water purity during egg-laying, which promotes offspring survival in the arboviral vector mosquito Aedes aegypti.
    1. Developmental Biology

    TALPID3 controls centrosome and cell polarity and the human ortholog KIAA0586 is mutated in Joubert syndrome (JBTS23)

    Louise A Stephen et al.
    Mutations in KIAA0586 (TALPID3) cause a severe ciliopathy called Joubert syndrome that affects organ, cell and centrosome polarity.
    1. Chromosomes and Gene Expression

    A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics

    Nicole A Rapicavoli et al.
    A long non-coding RNA regulates the expression of genes that encode proteins involved in the inflammatory response.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients

    Lakshmi E Miller-Vedam et al.
    Structure-function characterization of the EMC's cytoplasmic, transmembrane, and lumenal domains reveal features critical for terminal helix insertion and a specialized role for the lumenal domain in polytopic membrane protein biogenesis.
    1. Physics of Living Systems

    Deciphering the regulatory genome of Escherichia coli, one hundred promoters at a time

    William T Ireland et al.
    A combination of massively parallel reporter assays and mass spectrometry uncovers the regulation of previously unexplored promoters across the Escherichia coli genome.
    1. Developmental Biology

    Developmentally regulated Tcf7l2 splice variants mediate transcriptional repressor functions during eye formation

    Rodrigo M Young et al.
    The inclusion of a new alternatively spliced exon in Tcf7l2 can switch its function to repress transcription of Wnt target genes.