23 results found
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Quantitative analyses of T cell motion in tissue reveals factors driving T cell search in tissues

    David J Torres, Paulus Mrass ... Judy L Cannon
    The analysis of T cell movement in multiple tissues (lymph node, villi, and lung under two different inflammatory conditions) sheds new light on how T cells navigate different tissue environments to improve immunity and search processes.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Scorpionfish BPI is highly active against multiple drug-resistant Pseudomonas aeruginosa isolates from people with cystic fibrosis

    Jonas Maurice Holzinger, Martina Toelge ... Sigrid Bülow
    Bactericidal/permeability-increasing protein (BPI) from the scorpionfish Sebastes schlegelii escapes detection by BPI autoantibodies derived from people with cystic fibrosis and reveals excellent anti-inflammatory potency as well as profound antimicrobial activity towards Pseudomonas aeruginosa, including multiple drug-resistant strains.
    1. Cell Biology
    2. Computational and Systems Biology

    From actin waves to mechanism and back: How theory aids biological understanding

    Carsten Beta, Leah Edelstein-Keshet ... Arik Yochelis
    Mathematical methods reveal common underlying principles in diverse models of intracellular actin waves.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Sweepstakes reproductive success via pervasive and recurrent selective sweeps

    Einar Árnason, Jere Koskela ... Bjarki Eldon
    Selective sweepstakes from pervasive positive selection, rather than demographic changes or random sweepstakes reproduction, is the primary determinant of reproductive skew and genetic diversity in the highly prolific Atlantic cod.
    1. Ecology
    2. Microbiology and Infectious Disease

    Host-microbiome metabolism of a plant toxin in bees

    Erick VS Motta, Alejandra Gage ... Nancy Moran
    The bee gut microbiota contributes to the metabolism of the cyanogenic glycoside amygdalin.
    1. Developmental Biology
    2. Evolutionary Biology

    A novel cis-regulatory element drives early expression of Nkx3.2 in the gnathostome primary jaw joint

    Jake Leyhr, Laura Waldmann ... Tatjana Haitina
    Jaw joint regulatory sequence 1 (JRS1) is deeply conserved in most jawed vertebrates and displays a specific enhancer activity in the developing primary jaw joint that contributes to early nkx3.2 gene expression and jaw joint morphology.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice

    Clare M Smith, Richard E Baker ... Christopher M Sassetti
    A novel dual genome approach that combines genetically diverse mice and a library of bacterial mutants to define the genome-wide host pathogen interactions that drive distinct outcomes to tuberculosis.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Dynamically linking influenza virus infection kinetics, lung injury, inflammation, and disease severity

    Margaret A Myers, Amanda P Smith ... Amber M Smith
    Important nonlinear links between infection, inflammation, and disease severity were revealed using experimentally validated mathematical models.
    1. Immunology and Inflammation

    Cell-density independent increased lymphocyte production and loss rates post-autologous HSCT

    Mariona Baliu-Piqué, Vera van Hoeven ... Kiki Tesselaar
    Altered lymphocyte dynamics after hematopoietic stem cell transplantation cannot solely be explained by low lymphocyte numbers.
    1. Immunology and Inflammation

    The HIV-1 latent reservoir is largely sensitive to circulating T cells

    Joanna A Warren, Shuntai Zhou ... Nilu Goonetilleke
    HIV-specific T cells remain detectable for years in HIV-infected individuals on antiretroviral therapy and importantly, mostly (68%) recognize HIV viruses that have the capacity to rebound following treatment interruption.

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