Clare M Smith, Richard E Baker ... Christopher M Sassetti
A novel dual genome approach that combines genetically diverse mice and a library of bacterial mutants to define the genome-wide host pathogen interactions that drive distinct outcomes to tuberculosis.
Manoj M Lalu, Katrina J Sullivan ... Lauralyn McIntyre
A rigorous and transparent evaluation of mesenchymal stem cell therapy for sepsis suggests it may be efficacious, although the strength of these findings is tempered by threats to validity in the studies that were included.
Beth M Stadtmueller, Kathryn E Huey-Tubman ... Pamela J Bjorkman
The ectodomain of the human polymeric Ig receptor maintains a closed triangular shape that binds and excludes bacteria in mucosa, or opens to bind and transport polymeric Ig ligands across epithelial cells.
Hanno Teeling, Bernhard M Fuchs ... Rudolf I Amann
Dynamic successive blooms of clades of planktonic marine bacteria that can be observed during blooms of marine algae follow discernible patterns, part of which might be explained by substrate-induced forcing.
Comparing mice in clean and dirty environments reveals that environment drives initial establishment and size of T cell memory compartments, but not their maintenance in adults.
The analysis of T cell movement in multiple tissues (lymph node, villi, and lung under two different inflammatory conditions) sheds new light on how T cells navigate different tissue environments to improve immunity and search processes.