Jonas Maurice Holzinger, Martina Toelge ... Sigrid Bülow
Bactericidal/permeability-increasing protein (BPI) from the scorpionfish Sebastes schlegelii escapes detection by BPI autoantibodies derived from people with cystic fibrosis and reveals excellent anti-inflammatory potency as well as profound antimicrobial activity towards Pseudomonas aeruginosa, including multiple drug-resistant strains.
Reducing Akt-mediated huntingtin phosphorylation decreases APP accumulation at the synapse by reducing its anterograde axonal transport and ameliorates learning and memory in a mouse model of familial Alzheimer disease.
The analysis of T cell movement in multiple tissues (lymph node, villi, and lung under two different inflammatory conditions) sheds new light on how T cells navigate different tissue environments to improve immunity and search processes.
Comparing mice in clean and dirty environments reveals that environment drives initial establishment and size of T cell memory compartments, but not their maintenance in adults.
Hanno Teeling, Bernhard M Fuchs ... Rudolf I Amann
Dynamic successive blooms of clades of planktonic marine bacteria that can be observed during blooms of marine algae follow discernible patterns, part of which might be explained by substrate-induced forcing.
Beth M Stadtmueller, Kathryn E Huey-Tubman ... Pamela J Bjorkman
The ectodomain of the human polymeric Ig receptor maintains a closed triangular shape that binds and excludes bacteria in mucosa, or opens to bind and transport polymeric Ig ligands across epithelial cells.
Manoj M Lalu, Katrina J Sullivan ... Lauralyn McIntyre
A rigorous and transparent evaluation of mesenchymal stem cell therapy for sepsis suggests it may be efficacious, although the strength of these findings is tempered by threats to validity in the studies that were included.
