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    1. Developmental Biology
    2. Neuroscience

    Maturation of a central brain flight circuit in Drosophila requires Fz2/Ca2+ signaling

    Tarjani Agrawal, Gaiti Hasan
    Gene knockdown experiments in fruit fly pupae reveal the role of the signaling molecule 'dFrizzled2' in the development of a neural circuit that helps insects to fly continuously for extended periods.
    1. Neuroscience

    Modulation of flight and feeding behaviours requires presynaptic IP3Rs in dopaminergic neurons

    Anamika Sharma, Gaiti Hasan
    Motivation for flight and feeding behaviour requires dopamine release which depends on cholinergic stimulation and intracellular Ca2+ release from ER stores in one or two pairs of central dopaminergic neurons.
    1. Computational and Systems Biology

    A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice

    Michael A Petr et al.
    A comprehensive cross-sectional assessment reveals functional decline in mice consistent with increased energetic cost of physical activity with age through metabolic rewiring in multiple organs.
    1. Neuroscience

    A selective effect of dopamine on information-seeking

    Valentina Vellani et al.
    L-DOPA administration increases information-seeking about potential losses without impacting information-seeking about potential gains, and as a result, it reduces the effect of valence on information-seeking.
    1. Neuroscience

    A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice

    Ana S Machado et al.
    Analysis of 3D paw kinematics and whole-body coordination in freely walking mice isolates specific features of gait ataxia and supports the hypothesis that the cerebellum provides an internal forward model for motor control.
    1. Computational and Systems Biology
    2. Neuroscience

    Visuomotor learning from postdictive motor error

    Jana Masselink, Markus Lappe
    Visual, motor, and forward model gains learn from a postdictive update of space to keep perception and saccadic motor function aligned.
    1. Evolutionary Biology

    Changes to social feeding behaviors are not sufficient for fitness gains of the Caenorhabditis elegans N2 reference strain

    Yuehui Zhao et al.
    Use of experimental manipulation demonstrates that social/solitary feeding behaviors are unrelated to the fitness gains conferred by causative alleles in two previously identified genes.
    1. Neuroscience

    Drosophila larval to pupal switch under nutrient stress requires IP3R/Ca2+ signalling in glutamatergic interneurons

    Siddharth Jayakumar et al.
    The transformation of fruit fly larvae into pupae provides insights into the processes that enable animals to survive periods of food shortage.
    1. Neuroscience

    The manifold structure of limb coordination in walking Drosophila

    Brian D DeAngelis et al.
    During walking and turning, the fruit fly Drosophila uses variable limb coordination patterns, which exist on a low-dimensional, continuous manifold.