Rewiring of transcriptional circuits can preserve a basic output yet alter almost all of the circuit's quantitative and qualitative features.

Recent functional changes in ancient duplicate genes led to the evolution of divergent regulatory and metabolic strategies by the GALactose gene networks of two yeast species.

Yeast homologous chromosomes exhibit condition-specific mitotic pairing at both global and local scales.

Live-cell microscopy and genome-wide screens reveal how slow transitions in metabolism can underlie metabolic memory, providing a model for organisms demonstrating similar history-dependent behaviour and routes to improve industrial microbes.

The transfer of O-GlcNAc by EOGT to specific EGF repeats of NOTCH1 promotes DLL4 binding, Notch signaling, and retinal vascular development.

The secreted sugar-binding protein galectin-8 causes osteoblasts to secrete factors that promote the differentiation of bone marrow cells into osteoclasts; targeting this protein could therefore potentially help treat diseases associated with excessive bone loss.

Chemical perturbation-dependent deep mutational scanning data collected by a lab-based interdisciplinary graduate class resolves a paradox between the high evolution conservation and the high mutational tolerance of the protein ubiquitin.

RNA does not form DNA:RNA hybrids in trans that compromise genome integrity.

A yeast genetic model for studying the function of sister histones in chromatin dynamics.

A sharp transition in the fate of DNA ends with telomere sequences is identified, which suggests a boundary between DNA double-strand breaks and telomeres.