605 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Fusion surface structure, function, and dynamics of gamete fusogen HAP2

    Juan Feng et al.
    Structure, dynamics, and mutation of a gamete fusion protein and comparisons to viral homologues suggest that after trimerization the domain bearing the membrane-inserting fusion loops can pivot with respect to the trimer 3-fold axis.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Evolution of asymmetric gamete signaling and suppressed recombination at the mating type locus

    Zena Hadjivasiliou, Andrew Pomiankowski
    Selection for asymmetric signalling between gametes explains the very origins of sexual asymmetry as seen in mating-types with morphologically similar but self-incompatible gametes.
    1. Plant Biology

    Dynamic F-actin movement is essential for fertilization in Arabidopsis thaliana

    Tomokazu Kawashima et al.
    The movement of F-actin filaments, which is regulated by actin-myosin interactions together with a female gamete-specific Rho-GTPase, enables migration of the Arabidopsis sperm cell nucleus towards the female nucleus; which might account for the loss of centrosomes in flowering plants.
    1. Neuroscience

    An excitatory cortical feedback loop gates retinal wave transmission in rodent thalamus

    Yasunobu Murata, Matthew T Colonnese
    The absence of functional inhibition is a developmentally transient circuit property of corticothalamic feedback that is essential for the central transmission of spontaneous retinal waves.
    1. Neuroscience

    Inhibition gates supralinear Ca2+ signaling in Purkinje cell dendrites during practiced movements

    Michael A Gaffield et al.
    In behaving mice, inhibition from molecular layer interneurons attenuates excitation of Purkinje cells by parallel fibers and suppresses their ability to enhance climbing fiber-triggered dendritic Ca2+ responses.
    1. Cell Biology

    Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy

    Gian-Luca McLelland et al.
    A crucial step during the mitophagy cascade involves the disassembly of connections between mitochondria and the endoplasmic reticulum via the retrotranslocation of Mfn2 tethering complexes by the Parkinson's disease genes PARKIN and PINK1, as well as the ATPase VCP/p97.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Ion Channels: Taking a close look at a large-pore channel

    Pablo S Gaete, Jorge E Contreras
    The structure of pannexin 1, a channel protein with a large pore, has been determined for the first time.
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    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A CDC25 family protein phosphatase gates cargo recognition by the Vps26 retromer subunit

    Tie-Zhong Cui et al.
    The CDC25 family protein phosphatase Mih1 promotes downregulation of cell surface proteins in budding yeast by dephosphorylating a subunit of the retromer complex, which mediates plasma membrane recycling.
    1. Neuroscience

    Balance between BDNF and Semaphorins gates the innervation of the mammary gland

    Hadas Sar Shalom et al.
    The innervation of the mammary gland is controlled by opposing effects of neurotrophic and repulsive factors and, once trophic signaling is inhibited the repulsive factors, may promote axonal pruning.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Helical jackknives control the gates of the double-pore K+ uptake system KtrAB

    Marina Diskowski et al.
    The K(+) uptake system KtrAB is controlled by an allosteric mechanism entirely new for membrane channels, which operates the channel gate over a 35 Å distance.

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