34 results found
    1. Chromosomes and Gene Expression

    Histone H2B ubiquitylation represses gametogenesis by opposing RSC-dependent chromatin remodeling at the ste11 master regulator locus

    Philippe Materne et al.
    Building on previous work (Materne et al., 2015), it is shown that the ubiquitylation of histone H2B represses cell differentiation by opposing chromatin remodeling at the promoter of the master regulator of gametogenesis, ste11
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Multiple short windows of calcium-dependent protein kinase 4 activity coordinate distinct cell cycle events during Plasmodium gametogenesis

    Hanwei Fang et al.
    CDPK4 is a pleiotropic regulator controlling initiation of DNA replication, mitotic spindle assembly and flagellar activation during the early stages of Plasmodium transmission.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding

    Jixin Cui et al.
    Fam20A, a pseudokinase involved in the formation of tooth enamel, binds ATP in an unexpected orientation.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2

    Devanshi Jain et al.
    The mouse gene Ythdc2 exemplifies an evolutionarily ancient family of crucial regulators of the transition from germline stem cell divisions to meiosis.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Divergent kleisin subunits of cohesin specify mechanisms to tether and release meiotic chromosomes

    Aaron F Severson, Barbara J Meyer
    Mechanisms that tether and release replicated sister chromatids to produce sperm and eggs rely extensively on meiotic cohesin complexes that are endowed with unexpectedly different properties specified by a single interchangeable subunit, the α-kleisin.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    ATR/Mec1 prevents lethal meiotic recombination initiation on partially replicated chromosomes in budding yeast

    Hannah G Blitzblau, Andreas Hochwagen
    During meiosis, budding yeast use a checkpoint involving the protein Mec1 to prevent the formation of double-strand breaks in DNA that has not completed replication.
    1. Biochemistry and Chemical Biology

    Protein Kinases: What is the point of pseudokinases?

    Saravanan Raju, Andrey S Shaw
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    1. Neuroscience

    The Na+/Ca2+, K+ exchanger NCKX4 is required for efficient cone-mediated vision

    Frans Vinberg et al.
    Molecular, genetic, and functional analysis is used to show that the olfactory Na+/Ca2+, K+ exchanger NCKX4 is expressed in cone photoreceptors and is critical for the wide operating range and high temporal resolution of cone-mediated vision.
    1. Chromosomes and Gene Expression

    Promoter nucleosome dynamics regulated by signalling through the CTD code

    Philippe Materne et al.
    Phosphorylation of the C-terminal domain (CTD) of RNA Polymerase II controls nucleosomes dynamics at specific promoters to regulate transcription.
    1. Cell Biology
    2. Developmental Biology

    HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development

    Marisa Connell et al.
    HMMR regulates spindle positioning in neural and other cell types downstream of PLK1 and subsequently affects cortical NuMA-Dynein localization.

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