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    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2

    Devanshi Jain et al.
    The mouse gene Ythdc2 exemplifies an evolutionarily ancient family of crucial regulators of the transition from germline stem cell divisions to meiosis.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Divergent kleisin subunits of cohesin specify mechanisms to tether and release meiotic chromosomes

    Aaron F Severson, Barbara J Meyer
    Mechanisms that tether and release replicated sister chromatids to produce sperm and eggs rely extensively on meiotic cohesin complexes that are endowed with unexpectedly different properties specified by a single interchangeable subunit, the α-kleisin.
    1. Cell Biology
    2. Evolutionary Biology

    The wtf4 meiotic driver utilizes controlled protein aggregation to generate selective cell death

    Nicole L Nuckolls et al.
    The Wtf4 antidote protein assembles with the Wtf4 poison protein and promotes the transportation of the assembled proteins to the vacuole for sequestration or destruction.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Atypical meiosis can be adaptive in outcrossed Schizosaccharomyces pombe due to wtf meiotic drivers

    María Angélica Bravo Núñez et al.
    The wtf meiotic drivers change the fitness landscape of meiosis in outcrossed Schizosaccharomyces pombe demonstrating that genetic parasites can favor the evolution of variants that disrupt meiotic fidelity.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Individual long non-coding RNAs have no overt functions in zebrafish embryogenesis, viability and fertility

    Mehdi Goudarzi et al.
    Defining the biological functions of long non-coding RNAs, individually or as a class, and teasing apart the role of underlying genomic sequences remains the biggest challenge for this field.
    1. Cell Biology

    Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding

    Muqing Cao et al.
    During cilium-generated signaling, ciliary membrane protein trafficking is unidirectional and ciliary membrane protein composition is regulated through action in the cytoplasm of the retrograde intraflagelllar transport (IFT) motor and shedding of ciliary ectosomes.
    1. Cell Biology

    Meiotic cellular rejuvenation is coupled to nuclear remodeling in budding yeast

    Grant A King et al.
    A meiotic nuclear remodeling event mediates cellular rejuvenation through elimination of senescence factors.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity

    Wenke Wang et al.
    Two SET-domain containing proteins regulate H3K4me3 by their binding to H3K4me3 through their PHD domain and directly regulate expression of a subset of genes.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Post-meiotic DNA double-strand breaks occur in Tetrahymena, and require Topoisomerase II and Spo11

    Takahiko Akematsu et al.
    The first genetic compelling evidence for post-meiotic DNA double-strand breaks and its relation to chromatin remodeling in haploid pronuclei is shown.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolution of gene dosage on the Z-chromosome of schistosome parasites

    Marion A L Picard et al.
    An analysis of gene dosage at the DNA, RNA and protein level yields new insights into the early stages of Z-chromosome dosage compensation in schistosome parasites.