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    1. Cancer Biology

    FABP4-mediated lipid accumulation and lipolysis in tumor-associated macrophages promote breast cancer metastasis

    Matthew Yorek, Xingshan Jiang ... Bing Li
    FABP4 plays a central role in driving the formation lipid-laden macrophages induced by unsaturated fats and enhances macrophage-tumor interactions, thereby promoting breast cancer migration and metastasis.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin

    Nithin Sam Ravi, Beeke Wienert ... Kumarasamypet M Mohankumar
    Adenine and cytosine base editing of highly homologous HBG proximal promoter identifies novel target sites that result in adult to fetal globin switching without causing 4.9 kb large deletions.
    1. Neuroscience

    Disparity in temporal and spatial relationships between resting-state electrophysiological and fMRI signals

    Wenyu Tu, Samuel R Cramer, Nanyin Zhang
    There is a disparity in temporal and spatial relationships between resting-state electrophysiological and functional magnetic resonance imaging (fMRI) signals, suggesting the electrophysiological signal alone cannot fully explain the effects observed in the resting-state fMRI signal.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    ImmCellTyper facilitates systematic mass cytometry data analysis for deep immune profiling

    Jing Sun, Desmond Choy ... Shahram Kordasti
    ImmCellTyper enhances CyTOF data analysis by combining expert biological knowledge with advanced clustering tools to provide an accurate, comprehensive, and user-friendly solution for high-dimensional immune profiling.
    1. Neuroscience

    Optogenetically induced low-frequency correlations impair perception

    Anirvan Nandy, Jonathan J Nassi ... John Reynolds
    Low-frequency correlations among neurons in monkey visual area V4 impair the animal's ability to perform an attention-demanding task, suggesting a causal role of these fluctuations in perception.
    1. Cell Biology

    Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells

    Jennifer T Wang, Dong Kong ... Tim Stearns
    Deletion of delta-tubulin or epsilon-tubulin in human cells results in loss of centriolar triplet microtubules and defects in centriole structure and inheritance.
    1. Genetics and Genomics

    An in vitro approach reveals molecular mechanisms underlying endocrine disruptor-induced epimutagenesis

    Jake D Lehle, Yu-Huey Lin ... John R McCarrey
    The utility of an in vitro cell culture system for studies of molecular mechanisms underlying the initial induction and subsequent propagation of environmentally induced epimutations is demonstrated.
    1. Neuroscience

    Oscillatory hyperactivity and hyperconnectivity in young APOE-ɛ4 carriers and hypoconnectivity in Alzheimer’s disease

    Loes Koelewijn, Thomas M Lancaster ... Krish Singh
    Electrophysiology pinpoints brain function abnormalities in young people genetically at risk of developing Alzheimer's disease much later in life, supporting theories of initial hyperconnectivity driving eventual profound disconnection.
    1. Neuroscience

    Frequency-specific cortico-subcortical interaction in continuous speaking and listening

    Omid Abbasi, Nadine Steingräber ... Joachim Gross
    Distinct frequency-based interactions between cortical and subcortical regions highlight the cerebellum’s crucial role in speech production and perception.
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    1. Cancer Biology
    2. Immunology and Inflammation

    DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation

    Nicholas J Mullen, Surendra K Shukla ... Pankaj K Singh
    Cancer cell antigen presentation, a requirement for immune-mediated tumor rejection, is induced by dihydroorotate dehydrogenase-inhibitor-mediated cancer cell pyrimidine nucleotide depletion via P-TEFb-dependent transcriptional upregulation of MHC-I and related genes.
    Version of Record
    Research Article
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