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A single conserved residue – histidine 12 – confers pH-sensitive DNA binding to the Salmonella Typhimurium SPI-2 transcriptional regulator SsrB, thereby regulating Salmonella virulence.

Application of hierarchical machine learning to the geographical source attribution of Salmonella enteritidis indicates high utility for the rapid translation of raw pathogen genome sequencing data into accurate and actionable information for disease management in public health.

A combination of simulations and experiments was used to discover druggable cryptic pockets in non-structural protein 1, a promising but difficult target for coronaviruses, indicating a viable drug discovery approach for otherwise undruggable targets.

A cryo-EM structure of the SARS-CoV-2 M protein, the most abundant protein in the viral envelope, provides insight into its essential role in virus assembly.

A horizontally shared type VI secretion system affects the interaction between vibrios and eukaryotic hosts.

A multidisciplinary approach provides a description of the exocytic pathway that exports Salmonella Typhi's typhoid toxin from infected cells.

More parent-reported infections in the first year of life were associated with metabolic differences linked with cardiovascular and metabolic disease in adulthood, with observational evidence for inflammation partly mediating this relationship.

Horizontal gene transfer can potentially merge genomes from distinct bacterial species, but isolation in different hosts creates a physical barrier to gene flow.

A smartphone app incorporating clinical prediction models using patient-specific and location-specific data sources in a modular approach could predict viral-only etiology of diarrhea in children under five in Bangladesh and Mali.

Functional characterization of a pair of cis-encoded antisense RNAs reveals a role for RNase III and antisense regulation in the biogenesis and regulatory activity of a bacterial virulence factor-regulating small RNA.