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    1. Microbiology and Infectious Disease

    Structural basis of host recognition and biofilm formation by Salmonella Saf pili

    Longhui Zeng, Li Zhang ... Guoyu Meng
    SafDAA-SafDAA structure and functional characterizations reveal a pili-mediated inter-cellular oligomerization mechanism for bacterial aggregation and biofilm formation in Salmonella enterica.
    1. Microbiology and Infectious Disease

    Nanoscale organization of rotavirus replication machineries

    Yasel Garcés Suárez, Jose L Martínez ... Carlos F Arias
    Super-resolution microscopy reveals, at nanometric-scale, the highly organized protein structure of viroplasms, the viral factories used by rotavirus to replicate its genome and assemble new viral particles.
    1. Epidemiology and Global Health

    Lives saved with vaccination for 10 pathogens across 112 countries in a pre-COVID-19 world

    Jaspreet Toor, Susy Echeverria-Londono ... Katy AM Gaythorpe
    Vaccination activities that occurred before the COVID-19 pandemic, 2000-2019, are estimated to avert 50 million deaths, highlighting the enormous benefits of continued and improving vaccination.
    1. Microbiology and Infectious Disease

    Typhoid toxin sorting and exocytic transport from Salmonella Typhi-infected cells

    Shu-Jung Chang, Yu-Ting Hsu ... Jorge E Galan
    A multidisciplinary approach provides a description of the exocytic pathway that exports Salmonella Typhi's typhoid toxin from infected cells.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Post-phagocytosis activation of NLRP3 inflammasome by two novel T6SS effectors

    Hadar Cohen, Noam Baram ... Motti Gerlic
    A horizontally shared type VI secretion system affects the interaction between vibrios and eukaryotic hosts.
    1. Structural Biology and Molecular Biophysics

    Revealing druggable cryptic pockets in the Nsp1 of SARS-CoV-2 and other β-coronaviruses by simulations and crystallography

    Alberto Borsatto, Obaeda Akkad ... Francesco Luigi Gervasio
    A combination of simulations and experiments was used to discover druggable cryptic pockets in non-structural protein 1, a promising but difficult target for coronaviruses, indicating a viable drug discovery approach for otherwise undruggable targets.
    1. Evolutionary Biology

    The landscape of coadaptation in Vibrio parahaemolyticus

    Yujun Cui, Chao Yang ... Daniel Falush
    The first overview of fitness interactions within a species provides information how genetic interactions and ecology combine together to determine trait evolution.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Apoptotic signaling clears engineered Salmonella in an organ-specific manner

    Taylor J Abele, Zachary P Billman ... Edward A Miao
    Clearance of engineered Salmonella which trigger regulated cell death is dependent upon the cellular 'bucket list,' which is determined both by cell death signaling pathway and by cell type infected.
    1. Microbiology and Infectious Disease

    Vibrio deploys type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress

    Suneeta Chimalapati, Marcela de Souza Santos ... Kim Orth
    Considering the course of a pathogen's evolution, there appears to be interplay between secretion systems, providing unique, synergistic mechanisms to support a successful lifestyle for possibly pathogenesis, symbiosis and/or parasitosis.
    1. Microbiology and Infectious Disease

    The horizontally-acquired response regulator SsrB drives a Salmonella lifestyle switch by relieving biofilm silencing

    Stuti K Desai, Ricksen S Winardhi ... Linda J Kenney
    A response regulator acquired via lateral gene transfer has rewired an ancestral genetic circuitry and regulates alternative pathogenic lifestyles.