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Production of an amyloid protein by bacteria within the gut microbiome can influence the pathophysiology of a mouse model of synucleinopathy.

Genetic evidence in humans suggests that statins reduce cancer risk via a cholesterol-independent pathway.

The oral carbapenem 'Tebipenem' has high level antibacterial activity against highly drug-resistant Shigella, and its mode of action and pharmacokinetics make it suitable for the treatment of severe diarrhoea caused by highly drug-resistant bacteria.

High proportions of gut bacteria that produce their own food can be an indicator for poor gut health.

Editors' Summary: This Replication Study has reproduced important parts of the original paper.

Enteric bacteria associated with bloodstream infections are attracted to human serum through L-serine and the chemoreceptor Tsr, and in an enterohemorrhagic lesion model use chemotaxis to invade damaged vasculature.

Experiments in ex-germ-free mice establish a measurable effect of colonization history on gut microbiota assembly, illuminating a potential cause for the high levels of unexplained individuality in host-associated microbial communities.

Comparing tissue-specific plasma cfDNA concentration with cellular turnover rates reveals that less than 10% of dying cells' DNA reaches plasma, highlighting significant local clearance mechanisms and suggesitng approaches to enhance liquid biopsy sensitivity.

Lineage specifiers FoxA1 and FoxA2 control lung cancer growth and identity by activating gastric differentiation and suppressing squamous cell carcinoma transdifferentiation.

Indomethacin, a nonsteroidal anti-inflammatory drug, alters the composition of the intestinal microbiota, and the intestinal microbiota affect the pharmacokinetics of indomethacin.