A link between chronic stress and organ dysfunction is explained by the gateway reflex, in which brain micro-inflammation at specific vessels establishes a new neural pathway to induce fatal organ failure particularly in gastrointestine and heart.

Smoking is a risk factor for a broad range of gastrointestinal diseases independent of alcohol consumption.

The milk protein Mfge8 promotes fat uptake and slows gastrointestinal motility to optimize nutrient absorption.

High proportions of gut bacteria that produce their own food can be an indicator for poor gut health.

Asymmetric activation of the dysgranular mid-insula during interoceptive processing contributes to disrupted bodily awareness in individuals with anxiety, depression, and eating disorders.

Celastrol covalently inhibited the chaperone activity of GRP78 and could disconnect the transduction of ER stress signal to downstream inflammatory response and lipid metabolism.

Single-cell transcriptome analysis of sacral compared with vagal neural crest-derived cells in the developing chick enteric nervous system reveals both similarities and differences between these two cell populations.

Normalizing Tcf4 expression during early postnatal development improves behavioral outcomes in Pitt-Hopkins syndrome (PTHS) model mice, suggesting that genetic therapies are feasible in individuals with PTHS.

The absence of helminth parasites in developed countries may be exacerbating pathological, age-associated inflammation, known as inflammaging, suggesting that helminth therapies could provide protection against age-related disease.

Proton pump inhibitors are associated with an increased susceptibility to respiratory infections.