The Drosophila tracheal fate is stabilized by the combination of transcriptional programs to control tissue architecture and tissue-level input sensitive to tubular geometry, ensuring the robust mechanism of organ determination.
Analysis of axial polarity distributions shows that Wnt5a regulates collective cell migration in vivo by stabilizing vinculin at adherens junctions and fine-tuning mechanocoupling between neighbouring cells.
The Notch signaling pathway drives transitions in differentiation capacities during the gradual loss of potency that occurs in the preimplantation mouse embryo before the onset of the first lineage decisions.
At gastrulation, mesoderm arises as a migratory germ layer that will participate to both foetal and placental development through region-dependant adaptation of cytoskeleton composition, cell shape and migration mode.
mille-pattes micropeptides have conserved function in insect embryonic patterning together with transcription factor Shaven-baby and ubiquitin ligase Ubr3, except in flies wherein restoring broad embryonic Svb expression restores patterning potency.