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zGrad is a nanobody-based degron system that inactivates proteins in zebrafish
Naoya Yamaguchi et al.
The F-box/anti-GFP nanobody fusion protein zGrad depletes GFP-tagged proteins with spatial and temporal control in zebrafish.
Light-activated Frizzled7 reveals a permissive role of non-canonical wnt signaling in mesendoderm cell migration
Daniel Čapek et al.
Uniform activation of Frizzled7 signaling is required and sufficient for directional mesendoderm cell migration during zebrafish gastrulation.
Chromosomes and Gene Expression
Individual long non-coding RNAs have no overt functions in zebrafish embryogenesis, viability and fertility
Mehdi Goudarzi et al.
Defining the biological functions of long non-coding RNAs, individually or as a class, and teasing apart the role of underlying genomic sequences remains the biggest challenge for this field.
Primed Track, high-fidelity lineage tracing in mouse pre-implantation embryos using primed conversion of photoconvertible proteins
Maaike Welling et al.
Primed Track is an image analysis tool that allows for computational correction of drifting specimen to enable accurate lineage tracing of mammalian pre-implantation development even for larger imaging time intervals.
Immunology and Inflammation
HDAC3 restrains CD8-lineage genes to maintain a bi-potential state in CD4
thymocytes for CD4-lineage commitment
Rachael Laura Philips et al.
CD4 lineage commitment requires HDAC3 to prevent premature upregulation of CD8 lineage genes during T cell development.
Arid3a regulates nephric tubule regeneration via evolutionarily conserved regeneration signal-response enhancers
Nanoka Suzuki et al.
Arid3a, a component of H3K9 me3 demethylases, regulates regeneration of the proximal nephric tubule through the evolutionarily conserved regeneration signal-response enhancer.
Unique morphogenetic signatures define mammalian neck muscles and associated connective tissues
Eglantine Heude et al.
Genetic studies in the mouse provide a blueprint of the embryonic origins of neck muscles originating from cranial and somitic mesoderm, as well as associated connective tissue.
Control of neural crest multipotency by Wnt signaling and the Lin28/
Debadrita Bhattacharya et al.
The developmental potential of neural crest stem cells is regulated by a post-transcriptional mechanism that operates in a position-dependent manner.
Physics of Living Systems
Theoretical tool bridging cell polarities with development of robust morphologies
Silas Boye Nissen et al.
Biological shapes and morphological transitions can emerge from combining directed interactions between cells with apical-basal and planar cell polarity.
A novel mechanism of gland formation in zebrafish involving transdifferentiation of renal epithelial cells and live cell extrusion
Richard W Naylor et al.
A rare example of direct transdifferentiation is discovered in zebrafish in which kidney epithelial cells change into an endocrine gland and undergo live-cell extrusion from the renal tubule.
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