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    1. Developmental Biology
    2. Neuroscience

    Sustained expression of unc-4 homeobox gene and unc-37/Groucho in postmitotic neurons specifies the spatial organization of the cholinergic synapses in C. elegans

    Mizuki Kurashina et al.
    Genetic analyses using a simple nervous system of the nematode revealed the novel function of the cell fate-determining transcriptional repressor complex in the differentiated neurons to determine the precise synapse position.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Maternally inherited piRNAs direct transient heterochromatin formation at active transposons during early Drosophila embryogenesis

    Martin H Fabry et al.
    Maternally deposited Piwi-piRNA complexes co-transcriptionally repress transposable elements that transiently become active in somatic cells of the developing Drosophila embryo.
    1. Physics of Living Systems

    Live imaging and biophysical modeling support a button-based mechanism of somatic homolog pairing in Drosophila

    Myron Barber Child VI et al.
    Biophysical modeling and quantitative live-cell imaging converge to show that the century-old puzzle of somatic homolog pairing in Drosophila operates via a button model.
    1. Cell Biology
    2. Genetics and Genomics

    An actin-related protein that is most highly expressed in Drosophila testes is critical for embryonic development

    Courtney M Schroeder et al.
    Non-canonical ‘testis-specific’ actin-related protein (Arp), Arp53D, is critical for early embryonic development in Drosophila, revealing important roles for lineage-specific, divergent, testis-expressed non-canonical Arps outside the male germline in animals.
    1. Genetics and Genomics

    Establishment of H3K9me3-dependent heterochromatin during embryogenesis in Drosophila miranda

    Kevin H-C Wei et al.
    Heterochromatin is established at nucleation sites associated with open chromatin and RNA transcripts and matures into stable domains if they are found near transposable elements targeted by maternally deposited piRNAs.
    1. Computational and Systems Biology
    2. Developmental Biology

    Control of tissue development and cell diversity by cell cycle-dependent transcriptional filtering

    Maria Abou Chakra et al.
    A mathematical model predicts that cell cycle duration acts as a transcriptional filter and directly affects cell diversity in early eukaryotic development.
    1. Computational and Systems Biology
    2. Developmental Biology

    The pattern of nodal morphogen signaling is shaped by co-receptor expression

    Nathan D Lord et al.
    Ligand capture by cell surface receptor complexes sets the shape of the Nodal signaling pattern in zebrafish.
    1. Cell Biology
    2. Developmental Biology

    Dynamics of primitive streak regression controls the fate of neuromesodermal progenitors in the chicken embryo

    Charlene Guillot et al.
    Inverse gradients of cell ingression and division in the epiblast allow the bipotent progenitors in the anterior streak to become the main progenitors for posterior axis formation from the tail bud.
    1. Chromosomes and Gene Expression

    The molecular basis of coupling between poly(A)-tail length and translational efficiency

    Kehui Xiang, David P Bartel
    For poly(A)-tail length to influence mRNA translational efficiency, poly(A)-binding protein (PABPC) must be limiting, mRNAs lacking PABPC must be stable, and translation initiation must be sensitive to PABPC levels.
    1. Cell Biology
    2. Developmental Biology

    Apical PAR complex proteins protect against programmed epithelial assaults to create a continuous and functional intestinal lumen

    Maria Danielle Sallee et al.
    During intestinal development, apical PAR complex proteins keep apical domains and junctions continuous between cells as they divide and elongate, and ultimately build a continuous functional tube.