Browse the search results

Page 2 of 14
    1. Biochemistry and Chemical Biology
    2. Developmental Biology and Stem Cells

    The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis

    Karen Mendelson et al.
    Developing oocytes lacking Sphk2 sense high sphingosine levels and transcriptionally activate expression of the gene encoding Cers2b, to mediate a salvage pathway to reduce potentially toxic sphingosine.
    1. Structural Biology and Molecular Biophysics
    2. Developmental Biology and Stem Cells

    Quantitative imaging reveals real-time Pou5f3–Nanog complexes driving dorsoventral mesendoderm patterning in zebrafish

    Mireia Perez-Camps et al.
    Different combinations of the transcription factors Pou5f3, Nanog and Sox32 form complexes to drive dorsoventral mesendoderm patterning in zebrafish.
    1. Developmental Biology and Stem Cells

    Hox genes control vertebrate body elongation by collinear Wnt repression

    Nicolas Denans et al.
    The collinear activation of a subset of posterior Hox genes is responsible for establishing a Wnt/T activity gradient that is required to generate the complete body axis, and hence the full set of segments within a vertebrate embryo.
    1. Developmental Biology and Stem Cells

    The Apelin receptor enhances Nodal/TGFβ signaling to ensure proper cardiac development

    Ashish R Deshwar et al.
    The Apelin receptor acts as a rheostat to ensure that the proper levels of Nodal signaling are achieved for proper cell fate specification at the onset of gastrulation, in particular for cardiac progenitor development.
    1. Developmental Biology and Stem Cells

    The Natural History of Model Organisms: An organismal perspective on C. intestinalis development, origins and diversification

    Matthew J Kourakis, William C Smith
    The life cycle and morphology of the sea squirt Ciona intestinalis shed light on vertebrate evolution.
    1. Developmental Biology and Stem Cells
    2. Genetics and Genomics

    Establishment of regions of genomic activity during the Drosophila maternal to zygotic transition

    Xiao-Yong Li et al.
    Drosophila melanogaster embryos undergo a dramatic genomic transformation in the hour preceding gastrulation, as thousands of promoters and regulatory regions become biochemically distinct before they become active.
    1. Developmental Biology and Stem Cells

    Patterning and Axis Formation: Heterodimers reign in the embryo

    Benjamin Tajer, Mary C Mullins
    Experiments by three independent groups on zebrafish have clarified the role of two signaling factors, Nodal and Gdf3, during the early stages of development.
    Insight
    Available as:
    • HTML
    • PDF
    1. Developmental Biology and Stem Cells
    2. Chromosomes and Gene Expression

    Science Forum: Considerations when investigating lncRNA function in vivo

    Andrew R Bassett et al.
    We discuss the methods available to understand lncRNA function in vivo, and highlight important considerations that should be taken into account when designing such experiments.
    1. Cell Biology

    Unfolded protein response transducer IRE1-mediated signaling independent of XBP1 mRNA splicing is not required for growth and development of medaka fish

    Tokiro Ishikawa et al.
    The unfolded protein response sensor/transducer IRE1-mediated splicing of XBP1 mRNA encoding its active downstream transcription factor to maintain the homeostasis of the endoplasmic reticulum is sufficient for growth and development of medaka fish.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Planar cell polarity signaling coordinates oriented cell division and cell rearrangement in clonally expanding growth plate cartilage

    Yuwei Li et al.
    Through the interaction between PCP signaling and N-cadherin, oriented cell division and cell rearrangement are coordinated to establish the appropriate tissue architecture critical for limb skeletal morphogenesis.