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    1. Cell Biology
    2. Developmental Biology

    Wnt proteins can direct planar cell polarity in vertebrate ectoderm

    Chih-Wen Chu, Sergei Y Sokol
    Vertebrate early ectoderm displays planar polarity manifested by a fluorescent sensor and this polarity can be instructed by Wnt ligands.
    1. Developmental Biology
    2. Structural Biology and Molecular Biophysics

    Large, long range tensile forces drive convergence during Xenopus blastopore closure and body axis elongation

    David R Shook et al.
    Blastopore closure in Xenopus is driven by two morphogenic mechanisms that have strongly context dependent effects on tissue movement and that generate tensile force across tissues: convergent extension, as expected, and, unexpectedly, convergent thickening.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis

    Karen Mendelson et al.
    Developing oocytes lacking Sphk2 sense high sphingosine levels and transcriptionally activate expression of the gene encoding Cers2b, to mediate a salvage pathway to reduce potentially toxic sphingosine.
    1. Structural Biology and Molecular Biophysics
    2. Developmental Biology

    Quantitative imaging reveals real-time Pou5f3–Nanog complexes driving dorsoventral mesendoderm patterning in zebrafish

    Mireia Perez-Camps et al.
    Different combinations of the transcription factors Pou5f3, Nanog and Sox32 form complexes to drive dorsoventral mesendoderm patterning in zebrafish.
    1. Developmental Biology

    Hox genes control vertebrate body elongation by collinear Wnt repression

    Nicolas Denans et al.
    The collinear activation of a subset of posterior Hox genes is responsible for establishing a Wnt/T activity gradient that is required to generate the complete body axis, and hence the full set of segments within a vertebrate embryo.
    1. Developmental Biology

    The Apelin receptor enhances Nodal/TGFβ signaling to ensure proper cardiac development

    Ashish R Deshwar et al.
    The Apelin receptor acts as a rheostat to ensure that the proper levels of Nodal signaling are achieved for proper cell fate specification at the onset of gastrulation, in particular for cardiac progenitor development.
    1. Developmental Biology
    2. Immunology and Inflammation

    Chemokines: The cell sets the tone

    Jonna Alanko, Michael Sixt
    In zebrafish larvae, it is the cell type that determines how the cell responds to a chemokine signal.
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    1. Developmental Biology

    The Natural History of Model Organisms: An organismal perspective on C. intestinalis development, origins and diversification

    Matthew J Kourakis, William C Smith
    The life cycle and morphology of the sea squirt Ciona intestinalis shed light on vertebrate evolution.
    1. Developmental Biology
    2. Genetics and Genomics

    Establishment of regions of genomic activity during the Drosophila maternal to zygotic transition

    Xiao-Yong Li et al.
    Drosophila melanogaster embryos undergo a dramatic genomic transformation in the hour preceding gastrulation, as thousands of promoters and regulatory regions become biochemically distinct before they become active.
    1. Developmental Biology

    Patterning and Axis Formation: Heterodimers reign in the embryo

    Benjamin Tajer, Mary C Mullins
    Experiments by three independent groups on zebrafish have clarified the role of two signaling factors, Nodal and Gdf3, during the early stages of development.
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