Browse the search results

Page 2 of 23
    1. Developmental Biology
    2. Evolutionary Biology

    Maternally regulated gastrulation as a source of variation contributing to cavefish forebrain evolution

    Jorge Torres-Paz et al.
    Phenotypic evolution can originate from variations in very precocious developmental events, starting even before fecundation, during the fabrication of the egg in the mother's gonad.
    1. Developmental Biology

    Early patterning and specification of cardiac progenitors in gastrulating mesoderm

    W Patrick Devine et al.
    Multipotent cardiac precursors within a population of mesoderm are rapidly fated to specific anatomic locations in the developing mouse heart.
    1. Developmental Biology
    2. Structural Biology and Molecular Biophysics

    Gastrulation: May the force be with you

    Shinuo Weng, John B Wallingford
    Understanding the coordination of the forces generated in embryos by two processes, convergent extension and convergent thickening, is key to understanding how a hollow sphere of cells develops into an elongated embryo.
    Insight
    Available as:
    • HTML
    • PDF
    1. Developmental Biology

    The transcription factor Pitx2 positions the embryonic axis and regulates twinning

    Angela Torlopp et al.
    In higher vertebrates, the position of the embryonic axis (the location at which gastrulation starts) is determined by the transcription factor Pitx2, which suggests that the mechanisms of this process, and hence those that regulate twinning, are related to those that set up the left–right axis.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Zebrafish embryonic explants undergo genetically encoded self-assembly

    Alexandra Schauer et al.
    Blastoderm tissue organization and patterning in zebrafish explants is driven by a genetically encoded and controlled self-assembly mechanism, rather than a bonafide self-organization mechanism.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    The major β-catenin/E-cadherin junctional binding site is a primary molecular mechano-transductor of differentiation in vivo

    Jens-Christian Röper et al.
    The primary molecular mechanosensor involved in a physiological process of mechanically induced cell fate differentiation is revealed here for the first time in vivo, highly sensitive and potentially shared by all metazoan epithelia.
    1. Cell Biology
    2. Developmental Biology

    Wnt proteins can direct planar cell polarity in vertebrate ectoderm

    Chih-Wen Chu, Sergei Y Sokol
    Vertebrate early ectoderm displays planar polarity manifested by a fluorescent sensor and this polarity can be instructed by Wnt ligands.
    1. Developmental Biology
    2. Physics of Living Systems

    Theoretical tool bridging cell polarities with development of robust morphologies

    Silas Boye Nissen et al.
    Biological shapes and morphological transitions can emerge from combining directed interactions between cells with apical-basal and planar cell polarity.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis

    Karen Mendelson et al.
    Developing oocytes lacking Sphk2 sense high sphingosine levels and transcriptionally activate expression of the gene encoding Cers2b, to mediate a salvage pathway to reduce potentially toxic sphingosine.
    1. Developmental Biology
    2. Structural Biology and Molecular Biophysics

    Large, long range tensile forces drive convergence during Xenopus blastopore closure and body axis elongation

    David R Shook et al.
    Blastopore closure in Xenopus is driven by two morphogenic mechanisms that have strongly context dependent effects on tissue movement and that generate tensile force across tissues: convergent extension, as expected, and, unexpectedly, convergent thickening.