4,408 results found
    1. Neuroscience

    Decoupling sensory from decisional choice biases in perceptual decision making

    Daniel Linares et al.
    Perceptual decision making, even in simple scenarios, is affected by sensory and decisional choice biases.
    1. Structural Biology and Molecular Biophysics

    Molecular basis of force-from-lipids gating in the mechanosensitive channel MscS

    Bharat Reddy et al.
    The structure of the mechanosensitive channel MscS embedded in a lipid bilayer redefines the nature, location and importance of lipid–protein interactions in the gating of mechanosensitive channels.
    1. Structural Biology and Molecular Biophysics

    Irreversible temperature gating in trpv1 sheds light on channel activation

    Ana Sánchez-Moreno et al.
    Temperature-activated TRPV1 ion channels respond to increased temperatures by opening and then entering an inactivated state from which they cannot recover, suggesting that this form of irreversible gating results from partial unfolding during heat absorption.
    1. Neuroscience

    Calcium dynamics regulating the timing of decision-making in C. elegans

    Yuki Tanimoto et al.
    A series of quantitative behavioural and opto-physiological analyses using a novel robot microscope system reveals that C. elegans computes the time-differential and time-integral of sensory information for decision-making during olfactory navigation.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Protein biogenesis machinery is a driver of replicative aging in yeast

    Georges E Janssens et al.
    A comprehensive mapping of the proteome and transcriptome during the complete replicative lifespan of budding yeast predicted an increased abundance of the protein biogenesis machinery is most causal for aging.
    1. Neuroscience

    SIR-2.1 integrates metabolic homeostasis with the reproductive neuromuscular excitability in early aging male Caenorhabditis elegans

    Xiaoyan Guo, L René García
    A protein called SIR-2.1 helps to protect worms from the effects of aging by regulating metabolic processes that would otherwise generate damaging reactive oxygen species.
    1. Cell Biology

    Role of SAGA in the asymmetric segregation of DNA circles during yeast ageing

    Annina Denoth-Lippuner et al.
    The SAGA complex binds non-chromosomal DNA circles and prevents their spreading by attaching them to nuclear pores, thereby leading to the concomitant accumulation of DNA circles and pores in ageing yeast mother cells.
    1. Biochemistry and Chemical Biology

    Age- and diet-associated metabolome remodeling characterizes the aging process driven by damage accumulation

    Andrei S Avanesov et al.
    Aging is a process characterized by gradual metabolome remodeling, deceleration of the remodeling in late life and under conditions that extend lifespan, and a mortality-associated pattern of cumulative damage.
    1. Developmental Biology
    2. Genetics and Genomics

    celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish

    Chunmei Li et al.
    The use of forward genetic screens in zebrafish identifies a new model of vertebrate aging, defining the regulating of the onset of aging phenotypes through maintenance of progenitor cell populations.
    1. Structural Biology and Molecular Biophysics

    Regulatory switch at the cytoplasmic interface controls TRPV channel gating

    Lejla Zubcevic et al.
    C-terminal domain of thermoTRPV channels regulates channel gating at the cytoplasmic interface through a switch-like process.

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