7,925 results found
    1. Neuroscience

    Alcoholism gender differences in brain responsivity to emotional stimuli

    Kayle S Sawyer et al.
    Neuroimaging shows brain responses to emotional pictures are more diminished in alcoholic men than in alcoholic women, implicating gender-related mechanisms of addiction.
    1. Cancer Biology
    2. Cell Biology

    Different promoter affinities account for specificity in MYC-dependent gene regulation

    Francesca Lorenzin et al.
    Differences in promoter affinity and MYC levels explain distinct expression profiles induced by physiological and oncogenic MYC.
    1. Computational and Systems Biology

    Inference of gene regulation functions from dynamic transcriptome data

    Patrick Hillenbrand et al.
    Quantitative analysis of time-dependent transcription data elucidates the signal processing within the genetic network that regulates transcriptional cell cycle oscillations in yeast.
    1. Genetics and Genomics

    Divergence in alternative polyadenylation contributes to gene regulatory differences between humans and chimpanzees

    Briana E Mittleman et al.
    A comparative analysis of human and chimpanzee polyadenylation site usage establishes alternative polyadenylation as another key mechanism underlying the genetic regulation of transcript and protein expression levels in primates.
    1. Evolutionary Biology

    Evolution of Yin and Yang isoforms of a chromatin remodeling subunit precedes the creation of two genes

    Wen Xu et al.
    Gene sharing through different isoforms can precede the formation of independent genes.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Genomic architecture and evolutionary antagonism drive allelic expression bias in the social supergene of red fire ants

    Carlos Martinez-Ruiz et al.
    Analyses of allelic- and socially-biased gene expression reveal that suppressed recombination causes most of the expression differences in the social supergene, with only few differences due to socially antagonistic selection.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Computational prediction of CTCF/cohesin-based intra-TAD loops that insulate chromatin contacts and gene expression in mouse liver

    Bryan J Matthews, David J Waxman
    Certain types of 3D chromatin loops are easy to predict from existing or easily obtainable 2D information, which benefits gene expression studies in tissues/cells/organisms without extensive pre-existing 3D information.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Heterochromatin assembly by interrupted Sir3 bridges across neighboring nucleosomes

    Reza Behrouzi et al.
    Cooperative association of a histone-binding complex with pairs of appropriately modified nucleosomes, which form fundamental units of binding, mediates selective heterochromatin assembly and spreading.
    1. Cell Biology
    2. Immunology and Inflammation

    Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells

    Laura Marroqui et al.
    Pancreatic α and β cells have different cell autonomous signatures; this explains why α but not β cells can clear infections by potentially diabetogenic viruses.
    1. Ecology

    Experimental evaluation of the importance of colonization history in early-life gut microbiota assembly

    Inés Martínez et al.
    Experiments in ex-germ-free mice establish a measurable effect of colonization history on gut microbiota assembly, illuminating a potential cause for the high levels of unexplained individuality in host-associated microbial communities.

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